EXPERIMENTAL ANALYSIS OF MALIGNANT PUSTULE, ETC. 42 $ 
the carbuncular tumor will remain small and will subside after 
the third or fourth day without giving rise to general accident. 
On the first, the tumor will rapidly develop, assume enormous 
proportions, be surrounded by large swelling, the prepubic in¬ 
guinal bubons being very large and very painful. All that by 
the second day. There will be general intense fever, injection of 
mucous membranes, the temperature will rise to 411 ° to 42°, the 
general infection will appear imminent. Death may take place the 
fourth or fifth day, with extensive lesions of the lymphatic system, 
of the spleen, intestines, <fec. 
It is on killing animals at different periods of the evolution of 
our malignant pustule that we have been able to understand, 
sometimes the boundaries of accidents, sometimes their progres¬ 
sive march or their more or less rapid extension to the whole of 
the organism. Here is what we have observed : 
At the onset, that is, as far as the 12th, 20th, or even the 24th 
hour after the insertion of the liquid, the phenomena are the 
same in all cases. The morbid process is purely local; the irrita¬ 
tion of the skin and of the tissues does not extend beyond a 
radius of a few centimeters ; the oedema remains circumscribed ; 
the volume or aspect of the lymphatic glands has not changed. 
But from the 24th to the 48th hour, the first ganglions nearest 
to the pustule become diseased; the cellular envelope is infiltra¬ 
ted, their blood vessels dilated, their tissue becomes rosy, then red, 
by degrees purplish, and sometimes blackish ; they swell and have 
a tendency to break up into pulp, especially in the centre. The 
first buboes thus formed may, if very near the tumor, mingle with 
it and with the common oedema. 
It is in a successive manner that ganglions become diseased, 
and as they are on the way of traveling of the virulent elements. 
After the mammae and the inguinal, in the case of the pustule 
being near the posterior mammae, the pelvis, then the lumbar, 
thoracic, even the axillary become tumefied in one half of the 
body, if the pustule does not occupy the median line. 
A noticeable time, sometimes even quite long, may transpire be¬ 
tween the lesion of the first or fourth ganglion and that of the 
following. It seems that the first saturate themselves with viru 
