426 
M. COLIN. 
be slight or severe, whether or no there is serous exudation, sup¬ 
puration, ulceration, gangrene. This bacteridie or its germs, 
which, it is said, are preserved, even cultivated and grow in the 
cadaver, in putrified matters, dry or damp, for long years, die or 
are destroyed in a few days in the best carbunculous tumor, the 
richest in cellular tissue and blood-vessels, and the most impreg¬ 
nated of lymph or extravasated serosity. Indeed, all the pustules 
without fatal sequelae that I have examined from the beginning to 
the end, had lost virulency and bacteridies from the fifth and sixth 
day ; sometimes sooner. From this time neither the liquid from 
the canal or from the phlyctens, nor the pus, serosity or blood ob¬ 
tained by scarifications, nor the slough of the escharre diluted in 
water, have produced anthrax either in the rabbit or Guinea pig. 
The essay of these products has been carried out as far as the 
twelfth or fifteenth day, always with negative results. 
To judge of the value of the objections which would consist 
in saving: the bacteridie is not destroyed in the tumor, it is car¬ 
ried off by the circulation—I have looked for it in the remains 
of the infiltrations, in the spleen, the ganglions, the liquid of the 
thoracic duct, the blood, and even in some of the products of secre¬ 
tion, and that specially by the method of inoculation ; those al¬ 
ways remained sterile. 
It does not belong to me here to inquire why this aerobic be¬ 
ing lives, or seems to live, in a tumor closed for several days, dies 
there, or disappear after the dehiscence of that tumor ; why its 
disappearance corresponds exactly with the work of resolution or 
serous exudation, of suppuration, of the slough of the eschar. 
For the present, I can only state facts. 
To resume, animals known as refractory to anthrax contract 
malignant pustule, very well with or without oedema. This pus¬ 
tule or tumor takes many various forms, according to the points of 
the body where it develops itself. It aborts in parts where the 
skin is thick, and the cellular tissue dense; it grows, on the con¬ 
trary, with rapidity and assumes enormous proportions where the 
skin is thin, rich in lymphatics, in the neighborhood of ganglions, 
especially in the groin and on the matnmse; it is most often com¬ 
plete from the twenty-fourth to the forty-eighth hour. 
