EXPERIMENTAL ANALYSIS OF MALIGNANT PUSTULE, ETC. 427 
In all cases, without exception, the tumor is virulent; by the 
serosity of its canal, its blood, its extravasated liquids as by its 
oedema. This virulency lasts several days and gradually dies out, 
from the seventy-second to the eightieth hour, even often from 
the forty-eighth. 
The pustule disappears either by simple resolution, without 
opening, or after having serosity oozing out,/ in giving a dry es¬ 
char, in suppurating or ulcerating extensively. It moves spon¬ 
taneously with any one of these modes of transmission in nine- 
tenths of the cases of the adult subjects. 
Every time that the carbunculous tumor is accompanied with 
extensive lesions in the lymphatic ganglions, it has a tendency to 
produce a general state which often becomes fatal, especially in 
young animals. 
In the point of view of the diagnosis, microscopic examination 
of the elements and products of the tumor is far from furnishing 
positive characters ; for the tumor, of surely carbunculous nature, 
may not show any bacteridie in several of its products or layers, 
and the inoculation of those may remain sterile. And again, the 
virulency being ephemerous in the tumors that do not kill, it 
weakens and disappears without appreciable cause before the mo¬ 
ment of resolution, of ulceration or any other mode of transmis¬ 
sion. 
Considering the prognosis, the physical and microscopical 
characters of the tumors leave also the observer in doubt. The 
small tumor, with slow growth, which gives no anxiety, brings on 
general accidents and death as well as the most voluminous tumor, 
grown with rapidity. 
I conclude in giving as proofs and explanations, two tables, 
one indicating, in chronological order, the animals of canine and 
feline species upon which inoculations have developed accidents, 
followed by recovery or death ; the other showing the animals 
where inoculation remains sterile : 
The experiments of these tables are 153 in number. The mor¬ 
tality has been only of 23 in 153, cr 14 per cent., though there 
has not been any treatment; 130 remained sterile. In 62 cases 
