432 
GEORGE FLEMING. 
heifer was as successfully inoculated on the 13th of the same 
month. On the 19th there was a very fine vaccinal eruption, no 
fewer than sixty pustules being developed. Two other heifers 
were vaccinated from these, and so abundant w T as the lymph on 
the consecutive eruption that the Societe d’Hygiene was well sup¬ 
plied with material for vaccination purposes. In September of 
this year also, there was so severe an outbreak of horse-pox 
among the race-horses at Chantilly, near Paris, that several of 
them had to be struck off their engagements. 
I have stated that horse-pox and cow-pox are almost, if not 
quite identical in their effects, when transmitted by inoculation to 
man, the ox, or the horse. Cliauveau inoculated five horses and 
two asses witli animal vaccine from Naples; the youngest animal 
was seven years old, the others from sixteen to twenty years of 
age. For five and six days there were no signs, but in from five 
to eight days the seat of puncture became markedly papulous, 
the papules increasing in size until about the tenth day, when they 
were acuminated, had a very broad base, and were red, painful and 
hard. From the ninth to the twelfth day was the period of se¬ 
cretion, the epidermis becoming slightly raised throughout the 
wdiole extent of the papule by an exudation of limpid citron- 
colored serum; this dried into yellowish transparent crusts, very 
different in appearance from those of vaccinia in man or cow. 
The secretion from the lymph continued for several days, and 
ceased from the thirteenth to the seventeenth day. When the 
crust was removed there appeared a moist granular red surface 
level with the skin, but having a deep central cavity, a kind of 
umbilicus, in which had been fixed, like the head of a nail, the 
prominent under surface of the crust. There was no febrile re¬ 
action. In the asses there was shedding of the hair and epider¬ 
mis in various parts, with abundant serous exudation. As com¬ 
pared with its evolution in man and the cow, the vesicle or pustule 
was slower, and there was a difference in its shape and character, 
the pustule being acuminated, the lymph scanty, and the umbili¬ 
cus small or altogether absent; though in an ass sixteen years old 
the pustule had from the commencement a central umbilicus. In 
the horse the crust extends over all the pustule, while in man and 
