EXPERIMENTAL PHYSIOLOGY. 
277 
EXPERIMENTAL PHYSIOLOGY. 
COMPARATIVE INFLUENCE OF INTRA VENOUS INJECTIONS OF 
CHLORAL, CHLOROFORM AND ETHER UPON THE CIRCULA¬ 
TION. 
By M. Arlonig. 
To bring on anaesthesia and register the circulatory modification 
accompanying, we inject in the veins of a large animal chloral in 
solution of one-fifth chloroform and ether, in solution and sus¬ 
pension in a large quantity of water (20 pints). The necessary 
dose must be given several times, and each time slowly in a vein 
some distance from the heart. 
1st. If one takes, before and after the injection, cardiographic 
tracings with the instruments of Chauveau & Marcy, it is ob¬ 
served that the effects produced are not the same. All three 
agents produce an acceleration of the beatings of the heart, 
which is, however, greater and more active with the chloroform ; 
but one of them, the chloral, produces first a slackening, besides ; 
the chloral and ether lower the pressure in the right venticle, 
while chloroform increases it; again, this last or ether increas¬ 
es the strengtli of the systole, while chloral diminishes it. 
From this can be concluded that the pulmonary circulation is 
activated under the influence of chloral and ether and dimin¬ 
ished under that of chloroform. 
2d. We have simultaneously registered the modifications of 
the pressure and the changes of the rapidity of the current of 
the blood in arteries, before sleep and during the effects of the 
anaesthetic (the tracings being obtained with the new hemodrom- 
ograph of Chauveau), obtaining the following effects : Injections 
of chloral give first a slight increase of pressure, with a slight 
increase in the systolic current and diminution of the diastolic; 
soon they produce a falling of the pressure and an increase of the 
diastolic current which lasts till the end of the anaesthesia. Clilo- 
