368 
M. L. TRASBO'JT. 
immaculate. In admitting that tuberculosis, for instance, is trans¬ 
missible by this way, one is not justified to conclude in the result 
for all other affections, specially for the horse-pox. It seems to 
me then, that the certainty of vaccinal injection, through the 
digestive organs, is not yet surely established; that other new 
experiments are necessary to place it on undoubtful ground. 
By the injection of vaccine in the subcutaneous connective 
tissue, M. Chauveau has seen in all subjects, without exception, 
at tlie point where it was done, an inflammatory tumor resolving 
itself soon, and upon a few a generalized eruption of vaccinal 
pustules. 
Injected in the lymphatic vessels of eleven old horses, the 
vaccine lias given a generalized eruption in four. Similar injec¬ 
tions in the veins in twenty-seven animals were followed by 
positive results iu eleven cases. The young subjects gave the 
most success. 
All those experiments, whatever the number of positive results 
may be, as one alone in each series would be a certain proof, 
establish with certitude that the disease may be communicated 
by injection of the virus under the skin in the lymphatics or in 
the veins. This is incontestable. 
What were the causes of the quite numerous failures observed ? 
M. Chauveau looked into them. 
Thinking first that the vaccine which lie used might be of 
bad quality, he convinced himself that it was not by inoculating 
with success and comparatively other animals. Then lie thought 
the animals were not subject to the receptivity of the virus. He 
soon had to throw this idea aside, as he observed that, in the 
subjects submitted to the sub-cutaneous intralymphatic arterial or 
venous infection, the re vaccination with vaccine whose quality 
was known, failed also as well on those who had presented no 
symptoms as on those which had shown eruption after the injec¬ 
tion. 
He concluded that all had received the same impression from 
the first introduction of the vaccine, that there had not been any 
negative results, that the infection of the economy had taken 
place in the same manner on each animal. According to his idea, 
