102 
DR. OSLER. 
destroyed by the infiltration. The larynx and windpipe were not impli¬ 
cated. The lungs were edematous and contained, especially in the 
anterior lobes, a number of purulent deposits. On the skin of the clefts 
of the hoofs ol both front feet, a thick, diphtheric membrane existed. 
On visiting the place, five calves were found affected—two in the 
early stage, and two others seriously ill, while the death of the fifth was 
hourly expected. All were feverish, depressed and feeble, appearing 
stiff in their limbs, and disinclined to stand up. Saliva flowed from the 
mouth, and there was loss of appetite. The cheeks of several were swollen. 
Cough was an occasional symptom. Two of the calves were sent 
to Eldena in order that the course of the disease might be studied, and 
its contagiousness tested. They were put in a pen, and with them was 
placed a three days old calf. One of the above animals was not put 
under treatment. It was weak, salivated, had a yellowish discharge 
from the nose, a feeble cough, and copious diarrhoea. On the back of 
the tongue a thick, yellowish layer could be seen, which, subsequently, 
extended towards the tauces. Under the gradual increase of these symp¬ 
toms the animal died on the sixth day. At the post-mortem there were 
found diphtheritic colitis, scattered areas of consolidation (some of which 
were purulent,) in both lungs, and extensive diphtheritic patches in the 
throat and mouth; on the latter cavity affecting chiefly the tongue, the 
back part of which was covered with a thick membrane, beneath which 
the mucous and muscular tissue were to a certain depth destroyed. 
The other calf was treated with salicytic acid (30-40 grs. daily), and 
recovered in about three weeks. The attack did not appear so severe 
as in the first calf. Five days after being placed in the pen with the 
diseased animals, thejhealthy calf showed signs of the malady, and had 
the local and general symptoms as above described ; the membranous 
patches being well marked. It was also treated with salicytic acid, and 
recovered in five weeks. In all the cases numerous bacteria and micro- 
coccie were found in the membrane, and in the discharges from the nose 
and bowels. 
Severe cases proved fatal in four to five days; in others the duration 
of the disease extended over three weeks, and in these the onset of 
pneumonia fiequently determined the fatal result. In none of the 
cases observed was there any affection of the kidneys. Very young 
animals alone appear susceptible to the disease ; no instance was met 
with in half-grown or adult beasts. In both epidemics at Ludwigsburg 
almost every calf attacked died. The treatment recommended consists 
in syringing out the mouth and throat with a solution of salicytic acid> 
