TRANSLATIONS FROM GERMAN PAPERS. 
169 
TRANSLATIONS FROM GERMAN PAPERS. 
-«•>- 
HCEMOGLOBINURIA IN HORSES. 
By Bollinger. 
[Concluded^] 
Of the three important symptoms of this disease (hoemoglobinuria, 
albuminuria, and paralytic condition of the hinder extremities), the 
hoemoglobinuria (1) is regarded as the most characteristic. It is usually 
considered as hoematuria (bloody urine), in which condition, however, 
the urine is never lake colored, and microscopically red blood corpuscles 
can always be found. In hoemoglobinuria, on the other hand, the fil¬ 
tered urine has a peculiar lake color, like red wine, and contains no 
red blood corpuscles, but soluble hoemoglobin—the substance forming 
the chief constituent of the colored corpuscles, which can readily be de¬ 
tected by the spectroscope. Franck was the first to draw attention to 
this fact; and to show that the destruction of the blood corpuscle and 
solution of the coloring matter did not take place in the urine but in 
the blood itself; thus proving a change in this fluid to be a primary step 
in the process Reference is made to the interesting experiments of 
Ponfick, showing how this condition is produced after the injection of a 
certain amount of the blood of one species of animal into the veins of 
another. The foreign blood acts as a sort of poison, causing destruc¬ 
tion of the red corpuscles, and freeing the hoemoglobin, which escapes 
in large quantities with the urine. So long as the amount to be excreted 
is not too large, the kidneys do not suffer; but if considerable, anatomical 
changes are produced in these organs, an inflammatory condition 
arises, with great exudation into the tubules, rendering further excretion 
impossible and death results. 
(2.) — As is well known, not only hoemoglobin, but also tube 
casts, consisting of albumin, epithelium and granules, are found in 
the urine, indicating with certainty that an affection of the paren¬ 
chyma of the kidneys exist — a desquamative nephritis or acute 
Morbus Brightii. Depending upon this and strengthened by the 
examination of the diseased organs, many observers regard an inflam¬ 
matory state of the kidneys as the essential element of the disease ; but 
this afforded no explanation of the accompanying hoemoglobinuria. 
