280 
F. S. BILLINGS. 
describe them as lymphosarcoma. The lymphosarcomatose nature of 
these neoplasms is grounded (accorded to Virchow) upon the fact that 
giant cells are developed in the connective tissue matrix, from the con¬ 
nective tissue cells, also from the persistency of the elements lying in 
the spaces of the coarse reticalium, as well as from the progressive, 
sometimes very acute growth of these nodules, and metastasis accom¬ 
panying the same. 
Gerlach,* * * § Leisering,f Spinola,t and others have fed different ani¬ 
mals with nodules, tuberculose caseous masses, as well as with the milk 
and flesh of cows which have succumbed to perlsucht In these as well 
as m other animals which have been similarly treated, neoplasms develop 
in various organs,, and that the small nodules were observed to be very 
similar to the miliary tubercles of man. 
From these experimental researches as well as the explanation and 
clinical detail of perlsucht, led these investigators to the conclusion that 
peilsucht by cattle, and tuberculosis of the human subject were identi¬ 
cal, as Klebs § has already attempted to show in another way. 
Schiippel || examined the nodules (perlknoten) and tubercles histo¬ 
logically. He thought that both the nodule and the miliary tubercles 
developed out of giant cells, and that the giant cells were characteristic 
of both m diagnostic relations. Schiippel also based his assertions of 
the identity of nodules and miliary tubercle upon their histological 
construction. 
Gerlach, Leisering and others returned to Dupuy’s opinion. This 
opinion seems to have much stress for itself, but it is not universal as is 
shown by experiment, thus miliary tubercles develop themselves if they 
find a suppurative or a caseous center (Frankel and Cohnheim, Ruge), 
and especially from foreign bodies on the introduction of neoplastic 
detritus (carcinoma, sarcoma and others), into the organism, or from 
the products of retrogressive metamorphosis of tissues (Vulpian, Lebert 
Wyss). 
The following question was submitted to me by Prof. Virchow : 
“ What patho-anatomical changes take place in the mammary gland of 
the cow by perlsucht ?” I accepted this proposal with great pleasure, 
i, p. i. 
* Gerlach. VirchowVArchiv., vol. 51 , p. 29 o. Archiv. f. Thierheilkunde, Berlin, 1875 , vol. 
1 Leisering. Bericht uber das Veterinarwessen in Sachsen. 1864 and 1870 
+ Spinola - Handbuch d. Patholog. und Therapie. Berlin, 1858 Vol 2 
§ Klebs. Virchow’s Archiv., 1868, vol. 44 , p. 266; 1870, vol. 49 , p. 29I . 
|] Schuppel. Virchow’s Archiv., vol. 56, p. 38. 
