TRANSLATIONS AND EXTRACTS. 
297 
himself for the world. He was sure he would die if he had another 
spasm. After receiving a grain of morphia under the skin to be renew¬ 
ed every four hours, he was left quietly pacing up and down the room. 
He died during a violent attack of vomiting and spasms thirty-six 
hours after the first symptom. He had no cerebral symptoms, and said 
his sufferings were beyond description, with the exception of being 
quite free from pain during the intervals, and under the influence of 
chloroform, of which he spoke highly. 
Three men were bitten on the same evening by this dog. One 
went home without having the wound cauterized, and died within three 
weeks afterwards. The other two were well cauterized with nitrate of 
silver, followed by salt poultices. They are now at large in perfect 
health.— Veterinarian , Oct., 1877. 
TRANSLATIONS. 
By Dr. Osler, McGill University and Montreal Veterinary College. 
ON CHANGES IN THE BRAIN IN HYDROPHOBIA. 
By Dr. Forel, Privatdocent in Munich. 
Prof. Benedickt, in Virchow’s Archiv., 1875, p. 557, described a re¬ 
markable series of changes in the brain of a dog, and also of a man, 
dead of hydrophobia. These were (1) hyperoemia, hemorrhages, col¬ 
lections of red and white blood corpuscles in the adventitia of the ves¬ 
sels, and oedema of the brain substance. (2) secondary changes : mili¬ 
ary abscesses and granular degeneration of the brain substance in certain 
spots ; hyaline centres involving the destruction of nerve fibres and 
ganglion cells ; encircling of the vessels with pigment, and flakes of 
the same. He regarded these as produced by thrombosis of the veins, 
and held that they were of constant occurrence in all cases, being met 
with particularly in the region of the sylvian fissures, the olfactory 
centres, the nucleus of the motor root of the trigeminus, &c. These re¬ 
sults were confirmed in part by, the investigations of Kotesnikoff. To 
test the correctness of these views, Dr. Forel has examined the brain in 
two dogs, two horses, one ox, and a man, all dead of hydrophobia, with 
the following results : 
(1.) In the man there was found to a remarkable degree, filling of 
the capillaries and veins, and in some places, accumulations of white 
blood corpuscles in the adventitia ; nothing else abnormal. 
