/ 
A CONTRIBUTION. 
by the appearance of a general disturbance. The disease took its 
course in 16 to 20 days without any lethal terminations occurring. 
The transmission in this case was interposed by the variolic dis¬ 
eased attendants of the foals, and extended from the single infected 
foals to others. On the contrary, we are enabled to transmit human 
variola to cattle by way of inoculation, and thereby generate a di¬ 
sease strongly resembling the pure vaccina. We shall return to 
these very important experiments by the discussion of the genesis 
of variola vaccina, and will only here remark, that the variola 
vaccine won in this way generates, reinocululated to man, a local 
inoculatory pustule —without general exanthema. 
Sheep possess an insignificant susceptibility to the contagium 
of human variola; the inoculation with variolal-lymph complicates 
only 10 per cent., and it is asserted that the disposition to the ac¬ 
tion of ovine, or vaccine, is not in any way checked thereby. 
(Marson and Simonds) Gohier and Lullin have also successfully 
transmitted human variola to sheep. Kuchenmeister bound before 
a sheep for an hour or so, a sack containing a shirt which a pock- 
diseased man had worn, and on the fifth day the appetite of the 
sheep was disturbed, and on the eighth a distinct variolic eruption 
upon the woolless parts of the median surface of the thighs was 
perceptible. 
Viborg has reported the successful transmission of variola hu- 
mana to swine, and the same has been proved by experiment in 
Alfort, where they covered a cow with clothing impregnated with 
the contagium of human variola, which fell off from the same, and 
came in relation with some swine, which tore, and, perhaps con¬ 
sumed parts of the same; in from 8 to 10 days a variolic eruption 
appeared upon the swine; none of the 40 to 50 present being ex¬ 
empt from the same. Zuelzer has recently been successful in gen¬ 
erating artificial variola by monkeys, by means of inoculation with 
the blood of variola-diseased men, as well as by causing them to 
inspire air impregnated with contagium from eschars removed 
from the same. Greve also reports being successful in receiving 
positive results three times, from eight dogs which he inoculated 
from men. The three cases ended lethally. 
