146 
F. S. BILLINGS. 
to appearance, when we extend the cntis. The red hypersemic 
umbo may occasionally fail, or is only intimated; on the con¬ 
trary the subpustuloils cutis, sometimes also the subcutis, is in¬ 
flamed, indurated and distinctly prominent. Desiccation of the 
variolae begins on the eleventh or twelfth day, and a tolerably 
thick dark-brown eschar is formed, with liorn-like transparent 
edges. After the separation of the eschar, which takes place in 
the third week, we observe an oval or roundish cicatrix having 
little characteristic in its appearance, which remains apparent a 
long time. 
The non-concomitant eruption of the variolce which frequently 
comes to pass, is especially worthy of our attention; by means 
of it, we see fresh bull* and pustul* by the side of desiccated 
esehara. This important circumstance has been especially empha¬ 
sized by Bering and Reiter in opposition to the description of 
Sacco; and Reiter says expressly, that by the original bovine var- 
iol* the entire development of the variol* does not take place at 
one time, therefore they present a variable form and size; and 
that the retrograde processes correspond to this manner of devel¬ 
opment, so that the course of the individual variola is an acute 
one and completed in five or six days, and that developing and des¬ 
iccated variol* are present at the same time. The later erupting 
variol* have, however, the same virulent contents as those pri¬ 
marily developed. I shall have again to refer to this irregularity 
in the eruption of the bovine variolfe, which is full of aetiologi- 
cal importance. I will here remark, that in contradiction to the 
same, inoculated bovine variol* by cattle and man develop all at 
one time, mature at the same time, and are almost all alike in size 
and form. 
From the above, which has by far not exhausted the range of 
possibility, you may see how difficult it is to present a “ school 
picture ” which is able to represent all the various forms of bovine 
variolse; the same vary with regard to their eruption, their pit 
and umbo, their circumference, color; and it is easily conceiv¬ 
able that true variola vaccina may be as often mistaken and 
considered as a false form, as the contrary. 
{To be continued .) 
