A. CONTRIBUTION. 
193 
size from that of a pea to a ten cent piece, more or less thickly 
together upon the places in question, isolated upon other parts of 
the cutis; upon the neck of the animals circumscribed eczemata 
were observable. The nodes transformed in a few days to brown¬ 
ish eschars, which left behind them deep cicatrices. The setiolog- 
ical momenta remains unknown. The lymph from two undeveloped 
nodes was collected and sent to the inoculation station in Berlin. 
Inoculatory experiments with the same on several cattle gave 
negative results. By only one of the cattle in question there de¬ 
veloped in course of time an isolated variola, which, on being 
reinoculated through several generations, lead to the development 
of normal variolse. Variolse have been noticed upon the nose of 
As already mentioned, the diagnosis of variola? vaccina? is 
sometimes accompanied by certain difficulties, a circumstance 
which is grounded in the unfrequency of the processes, as well as 
in their sporadic appearance. I will not here enter into an inti¬ 
mate discussion of the so-called variola vaccina spuria, the accu¬ 
mulated, indurated, and varicella-like variola?—which are often 
mistaken for the true eruption. We also find variol?e-like exan¬ 
themata upon the udder of the cow by some infectious disease. 
By apthse epizooticse are frequently met with variolas-like noduli 
and nodi, which are gradually transformed into pustulse and large 
confluent bullae. The contents is fluid, and generally of an in¬ 
tense yellow color. According to Reiter, inoculation with the 
same gave negative results, while in other cases positive results 
are said to have been attained. 
By the nasal-diphtheria of cattle we also find a herpes-like ex¬ 
anthema upon the udder, which can however, scarcely be compli¬ 
cated with variola. 
As a severe form of variolas which extended over the entire 
body of the diseased cattle, and which was directly compared with 
v. liumana, a disease was described in the last century, which 
appeared in Lombardy, in Holland, Holstein, and in a very 
malignant form in England (Layard), and occasioned great devas¬ 
tation. A similar malignant form of variolas is said to have pre¬ 
vailed in East India in the fourth decennium of the present cen- 
