T "f 33J 
155119 
30' ANNÉE JANVIER 1916 N» 1 
ANNALES 
DE 
L’INSTITUT PASTEUR 
Mémoire publié à l’occasion du jubilé de M. E. Metchnikoff. 
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CERTAIN ALTERATIONS IN BIOLOGICAL PROPERTIES 
ÔF SPIROCHAETES , 
THROUGH ARTIFICIAL CULTIVATION 
by HIDEYO NOGUCHI. 
(From the Laboratories of llie Rockefeller Inslilute for Medical Research.) 
A new era in the experimental resoarch of syphilis was 
opened out hy Metchnikoff and Roux when lhey sncceeded in 
transmilting syphilis to anthropoid apes (I). It was they also 
who furnished the experimental syphilitic material in which 
Treponema pallidum was First demonslrated, this microorganism 
having in the meantime heen found by Schaudinn and Hoff¬ 
mann to be présent in liuman syphilis. By this means one of 
the re qui site postulâtes for the establishment of the etiological 
relation between Treponema pallidum and syphilis was pro- 
vided. To the pioneer work of Metchnikoff and Roux we are 
indebted for many of the subséquent developmcnts in the field 
of experimental syphilis. 
(1) Metchnikoff et Roux, Annales de l'Institut Pasteur, 1903, 1904, 1905, 1906, 
1907; — Bull, de l'Acad. de Méd ., Paris, t. LXIX, n° 20, ancl Bull, méd., 1905, 
p. 441. 
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