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ANNALES DE L’INSTITUT PASTEUU 
pneumococcal meningitis apparentlywith a successful resull [10]. 
Tabes Dorsalis and Paresis. — The discovery by Noguchi of 
Treponema pallidnm in lhe brain in paresis and in the spinal 
cord in tabes bas opened up these affections lo spécifie therapy. 
Even before this discovery Swift and Ellis employed on 
general anatomical grounds a method of local spécifie therapy 
in the treatment of tabes dorsalis [11]. The method consists 
in the subarachnoidal injection of salvarsanized sérum, obtained 
from the hlood of patients following an intravenous injection 
of salvarsan. This sérum, suitably diluted, is introduced into 
the spinal méningés. The results obtained bave been highly 
encouraging and a similar procedure is now being tesled in 
the local treatment ot paresis. It would therefore seem dési¬ 
rable, on theoretical grounds, toemploy the local method, along 
with general spécifie médication, in the treatment of sleeping 
sickness. 
Tuberculous Meningitis. — Tuberculosis of the serous mem¬ 
branes can be readily induced in animale by injecting an 
émulsion of tubercle bacilli into the serous cavities. In this 
manner tuberculosis ot the pleura and of the méningés has 
been produced in the dog and the monkey. When left untreat- 
ed the lésions progress and terminate the life of the animal ; 
but their progress has been retarded by injecting living leucô- 
cocytes locally into the site of the tuberculous lésions. By 
means of repeated subdural injections of dog leucocytes, tuber¬ 
culous meningitis in the dog has been either arrested or 
healed ; and experimental tuberculosis of the méningés in the 
monkey has been favorably affected by local injections of rab- 
bit’s leucocytes [12]. 
Other applications. 
lt is obvions that local spécifie lherapy in the manner here 
indicated is applicable to other parts of the body than the 
central nervous System. The antimeningococcal sérum has 
indeed been successfully employed in the local treatment of 
metastatic meningococcal arthritis. Syphilitic keratitis in the 
rabbit has been healed by local instillations of neosal- 
varsan [14], and ulcus serpens by the local use on the one 
