LEUCOCYTES IN METABOLISM OF CARBOHYDRATES 
159 
substance four hydrogen aloms of glucose are substituted. 
Ail substitutions are in the alcoholic groups. In the other 
substances only one hydrogen of the glucose molécule is suh- 
stituted, but the place of substitution is not the saine in ail 
substances. Il was found that under the conditions of the 
experiment only mallose underwent the same décomposition as 
glucose. The other substances remained intact. The cause 
of lhe ditferent behaviour of the varions sugar dérivatives is 
explained hy the fact that animal cells contain an enzyme 
which décomposés mallose into glucose, but they lack the 
enzyme which cleaves the other substances into their compo- 
nents. The results of these experiments show that substitu¬ 
tion of a hydrogen atom in the glucose molécule lends to the 
substance résistance towards glycolylic enzymes. This con¬ 
clusion is of considérable importance in connection with some 
recent théories of diabètes. It was claimed hy some writers 
that sugar is not utilised hy the organism unless it had an 
opportunity to enter into Chemical union with some other 
substances. This theory is not sustained hy our experiments 
with conjugated glucoses. 
Conclusions. 
1) Six carbon chain-sugars in course of their catabolism are 
transformed into methylglyoxal. This in its turn is converted 
into lactic acid. 
2 ) The phases leading to the formation of methylglyoxal and 
those leading to the conversion of lactic acid to carbon dioxide 
into water are not yet known. 
3) Ilexoses in which one or more hydrogen atoms are substi¬ 
tuted by other radicles are no longer affeeted hy the glycolytic 
enzymes of animal (issues, unless the substituting group had 
been removed. 
