mised that where flukes lie in the blood, as do the blood flukes, or 
feed on blood, as does Fasciola hepatica, anthelmintic treatments for 
their destruction will probably be developed, but that flukes which 
are encysted, as P. westermani or Agamodistomum suis, or which 
do not feed on blood, as Dicrocoelium dendriticum, will be distinctly 
more difficult to destroy by anthelmintic treatment, though the possi¬ 
bility of accomplishing their destruction in this way is by no means 
out of the question. D. dentriticum might be amenable to anthel¬ 
mintics eliminated in the bile. 
CESTODE MEDICATION 
In the case of cestodes outside of the lumen of the digestive 
tract, little has been accomplished as yet in the way of anthelmintic 
treatment. For the most part, such cestodes are larvae encysted in 
tissues, and while the growth of these larvae shows that they absorb 
solid and fluid material from their host, the growth is slow and it is 
evident that the absorption is very slow, a feature which promises 
little for the success of anthelmintic treatment. Ziirn (1882) was 
unable to find a drug that would destroy the gid parasite in the 
brain of sheep in the course of 24 years’ experiments along this 
line. Hall (1909) and Moussu (1910) found repeated doses of male 
fern ineffective in gid in sheep, the parasites being found alive after 
the conclusion of the treatment. Feletti (1894), de Renzi (1908) and 
Dianoux (1909) have reported cures of a total of 6 cases of cysticer- 
cosis in man following repeated doses of male fern. Moussu (1910) 
was unable to cure a similar case of cysticercosis in a pig by this 
treatment. De Renzi (1908) reported the cure of 2 cases of hydatid 
disease in man by the administration of repeated doses of male fern, 
but Deve (1911) was unable to obtain similar results in cases of 
hydatid infestation in rabbits. Deve and Payenneville (1914) found 
repeated injections of neosalvarsan intravenously of no value in pre¬ 
venting the development of hydatids in rabbits. Recently, Deve and 
Payenneville (£922) have reported the same negative results with 
novarsenobenzol. 
70 
