Of the adult cestodes occurring outside of the lumen of the 
digestive tract, we find such forms as Thysanosoma actinioides in 
the bile ducts. Curtice (1889; 1890) was unable to find a satisfactory 
treatment for these worms in tests with pumpkin seed, pomegranate- 
root bark, koosoo, kamala, male fern, and worm seed. Stiles (1902) 
found arsenic of no value against fringed tapeworm. Ransom and 
Hall (1912) were unable to destroy these fringed tapeworms by 
means of repeated doses of carbon bisulphid or of male fern. 
The findings in many of the cases dealing with the treatment of 
intestinal and of somatic taeniasis are somewhat vague or uncertain 
and it is necessary to reserve judgment in these cases as regards the 
efficacy or inefficacy of the treatment. Undeniably the results ob¬ 
tained in attempts at treatment to destroy tapeworms outside of the 
lumen of the digestive tract are inferior to those obtained in the case 
of certain flukes. Probably these tapeworms are less susceptible to 
anthelmintic treatment than are the flukes in question, but more 
work is necessary along this line. 
NEMATODE MEDICATION 
The nematodes outside of the lumen of the digestive tract, like 
cestodes so situated, are less amenable to anthelmintic treatment than 
are the trematodes. The reason for their resistance does not appear 
to be the same as in the case of cestodes. Many of these nem¬ 
atodes are not encysted and some of them must feed on blood or 
lymph. While the nematode cuticle may be thought to be more re¬ 
sistant than the corresponding structure in flukes or tapeworms, it 
must be borne in mind that certain drugs will destroy nematodes in 
the lumen of the digestive tract in cases where the same drugs 
entirely fail to show any adverse effect on flukes or tapeworms 
similarly situated. The reverse of this is, of course, true. It ap¬ 
pears, therefore, that we must consider the action of anthelmintics 
as more or less specific and that the question of penetration is of 
little moment, whereas the finding of a suitable drug is of prime im¬ 
portance. In a general way it may be said that other things being 
