animals becoming heavily infested. This claim requires confirmation. 
At the present time we know of no drug that has been definitely ascer¬ 
tained to kill trichinae in the muscles. 
TREATMENT OF FILARIDS 
Aside from trichinae, the worms which have received the most 
attention from the standpoint of medicinal treatment are the filarids. 
The papers on this subject do not indicate that much of a definite 
and positive nature has yet been established. Schultz has reported 
success in killing the adult Loa loa in the connective tissue of man, 
together with the larvae in the blood, by the administration of a 1 
per cent solution of collargol in dessertspoonful doses three times a 
day for over a year. Thiroux and d’Anfreville (1910) report the 
disappearance of L. loa in a patient treated with aniline tartrate. 
Morlot and Zuber (1914) report the disappearance of this worm fol¬ 
lowing injections of neosalvarsan. Rogers (1919) and Das (1920) 
have reported favorably on tartar emetic in infestations with Filaria 
bancrofti, but Low and Gregg (1920), Macfie (1920) and Low and 
O Driscoll (1921) report unfavorably on this drug, Macfie’s cases in¬ 
cluding infestations with F. bancrofti, F. perstans and L. loa. Low 
and O’Driscoll found emetine also ineffective, and though Miihlens 
(1921) has seen filariae disappear from the blood after emetine, he 
regards this as spontaneous or accidental, another case showing no 
results after emetine, tartar emetic and neosalvarsan. Siebert (1920) 
found that filariae disappeared in the case of an undetermined species 
of filarid after treatment with picric acid and refers to Scheube (1910) 
as having seen the microfilariae of F. bancrofti die in the blood after 
the administration of potassium picrate. Ikegami (1920) reported 
that after 2 injections of arsaminol (Japanese salvarsan) in the case 
of one patient, the microfilariae disappeared from the blood and the 
urine became clear; no chyluria or other symptoms reappeared in 
over a year. Curasson (1920) reports that he treated 3 carrion 
73 
