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lias been used as a pasture for native liorses and cattle for many 
years. 
The symptoms are fairly constant varying witli the progress 
and stage of the disease. The first indications may be weakness, 
émaciation, or pyrexia. There is a progressive anaemia, an irre- 
gular pyrexia, —• the température ranging between ioo° and 105*". 
Emaciation is a constant sign excepting in the very aciite cases'^; 
of iinder two weeks duration. At the onset the appetite may be 
poor, but later the animais will consume enormous quantities of 
food, il permitted, yet in spite of this the émaciation continues. 
Conjunctival ecchvmoses, particularlv in the nictitating mem¬ 
brane, are seen. When the anaemia is well advanced the conjunc¬ 
tival and nasal mucosae are pale and muddy. In a few animais 
there lias been oedema of the sheath or dépendant abdominal 
wall. Weakness of the loins and posterior extremities is observed 
a few days before death. 
The disease runs an acute, subacute or chronic course. Acute 
cases hâve died one or two weeks after the appearance of émacia¬ 
tion, weakness or pyrexia. Most of the mules hâve been sick 
two or three weeks to two months. One horse has been eniaciated 
and had occasional febrile paroxysms for six months while trypa¬ 
nosomes hâve been présent in his blood for three months. 
A nuniber of the animais hâve been sacrificed as soon as a 
diagnosis had been made, but when a mule is permitted to die 
of the disease, the lésions are usually characteristic. Emaciation 
is always well niarked in ail save acute cases. Conjunctival ec¬ 
chymoses are usually seen. There are large epicardial and endo- 
cardial haemorrhages. The parenchvma of the kidnevs is swol- 
len,oedematous and pale, and cortical ecchymoses (i mm. in dia- 
meter) are always seen commonlv just beneath the capsule. 
The outer surface of the spleen generalIv is dotted over with 
small brown and red ecchymoses 2 mm. in diameter confinée! to 
the capsule. 
There may be peritoneal or pleural ecchymoses. The rénal 
lymph nodes are often swollen and red, and sonietimes contain 
extensive haemorrhagic nécrosés. 
Microscopically there is little to add to the anatomical diagno¬ 
sis save the occasional presence of minute hepatic nécrosés con- 
fined to one or two hepatic cells. The hepatic cells usually con¬ 
tain large dark colored granules not definitely bile nor hemozoin. 
