— 5 oo — 
cess as entirely satisfying ail the conditions of latency and re¬ 
lapse. He concludes : 
(( 1.— Intracorpuscular conjugation is the principal cause of the 
maintenance of malarial infection in man, an its absence the 
cause of spontaneous recovery. 
(( 2.— It maintains malarial infection by producing a « resting » 
or zygote stage of the plasmodia, which is résistent to quinine 
and other injurions inlluences. 
(( 3.— It is the cause of latent and récurrent malarial infections, 
the zygote stage remaining dormant or u latent » until condi¬ 
tions are fayorable, yhen it giyes birth to seyeral young plasmo¬ 
dia which penetrating the red blood corpuscles, by their growth 
and sporulation, cause a récurrence of the infection. » 
The strongest argument in fayor of intra-corpuscular conjuga¬ 
tion as a preseryatiye process of the malarial parasite is the fact 
that conjugation is not uncommon among the protozoa and while 
it is true that it is usually a sexual conjugation there are ins¬ 
tances where sex in the conjugating bodies cannot be differen- 
tiated. It is ordinarily obseryed in these low organisms where 
reproductiye yitality is at a low ebb and seems to be merely a re- 
juyenating process by which normal reproduction is inyigorated. 
On the other hand intracorpuscular conjugation in malaria has 
been obseryed most typically in seyere infections, where plural 
infection of red cells is common, where the organisms seem viru¬ 
lent, and not in those cases where the parasites are scanty and the 
symptoms slight. 
It is my opinion that conjugation in protozoa in general has 
its analogue in the conjugation of microgamete and macrogamete 
in the body of anopheline mosqtiitoes, every step of whose life 
history has been traced from zygote to sporozoit. That intracor¬ 
puscular conjugation occurs in malaria is probable but its im¬ 
portance in the etiology of relapses at long intervals is probable 
minimal. It is in ail probabilité merely a rejuvenating process v 
schizogony and thus far may hâve an indirect rôle in relapses at 
short intervals. It seems probable that the product of conjugation 
is not a a resting body », at least such has not been demonstra- 
ted, the conjugating bodies having been traced no farther than 
union. While Craig (3) refers to certain large bodies similar to 
gametes, no relation is established between them and conjuga¬ 
tion. 
