malaria uaderwent a parthenogenetic cycle of clevelopement whe- 
reby the species was perpetuatecl after the death of the schizonts. 
He cued a niimber of arguments in support of the theory and re- 
ferred to a similar process in other protozoa, Adclca, Trichos- 
pherium and Volvox. 
It was vScHAiîDiNN (9) who in 1902, first observed and correctly 
mterpreted parthenogenesis of tertian macrogametes. It is unne- 
cessary to recount the details of these observations here. Suffice it 
to sav that everv step in the clevelopement of the parasite was 
followed and definite relations between its growth and latency 
and relapse established. Macrogametes were seen to sporulate 
producing merozoits vrhich in turn underwent ncjrmal schizogony. 
Maurer (10), in 1902, observed sporulation of estiva-autumnal 
gametes, and construecJ it as parthenogenesis. 
ZiE.MAVN (il) believes that he has seen parthenogenetic repro¬ 
duction of cpiartan gametes. 
Blüml and Metz (12) observed sporulating macrogametes in 
six préparations taken from five patients with tertian malaria. 
1 die process was identical with that described bv Schaudinn. 
Young and sporulating schizonts and young gametes were pré¬ 
sent in these same préparations. 
Karrewey is reporter! to hcuve confirmed the observations of 
Schaudinn upon tertian macrogametes. 
Fintdlv Neeb, 1910, has made a very interesting report upon 
parthenogenetic processes in female crescent boches, obtained 
from the blood of a chronic malarial subject. The specim.ens were 
shown to Prowazek and to Nocht wTo confirmed the opinion that 
thev were sporulating macrogametes. 
A similar parthenogenetic process observed among the trvpa- 
nosomes, particularly Trypanosoma gambicnse and Trypanoso- 
ma Ic-2visi should be referred to. 
It appears to me that parthenogenesis, first observed and cons- 
trued by the most eminent protozoologist the Avorld has ever pro- 
duced and whose observations hâve been repeatedly confirmed, 
must be acceptée! as the true explanation of chronic malaria. 
Secondary etiological influences play a much more prominent 
rôle in relapses than in primary infections. Of these the most 
important are changes of résidence, fatigue, abuse of alcohol, 
exposure and gastro-intestinal disturbances. Ail are familiar with 
the fréquence with which a change of résidence « brings the ma- 
