— 635 — 
those in the lowermost layer of the epidermis and in the external rootsheath 
of the hair-follicle. The épithélial masses may be distinct or made up of 
intercommunicating bande and tracts, in some places resembling cell-ducts. 
Cell (( nests » are met with as in malignant epithelioma, enclosing horny, 
granular and colloid tissue. Colloid degeneration of individual cells is also 
encountered in the cell masses. The connective tissue about the cell collec¬ 
tions is somewhat condensed, but is not the seat of any inflammatory pro- 
cess ». 
It must be confessed that for the most part this description applied very 
well to the earlier sections studied and it was found that Allan Jamieson 5 
quoting various authorities speaks of épithélial cystadenoma as a species of 
acanthoma while the description he gives does not differ markedlv from that 
stated above. 
It will perhaps be interesting also to consider some of the latest utterances 
in English or American text-books on the histo-pathology of true oriental 
sore. 
Manson 6 says little — a Section of the papule displays an infiltration of 
the derma by a mass of small round granulation cells. These lie between 
the éléments of the tissues, particularly about blood-vessels, lymphatics and 
sweat-glands, towards the centre of the lésion they completely replace the 
normal structures ». 
Wright 7 in his original paper States that « the lésion consists essen- 
tially of a very extensive infiltration of the corium and papillae by cells, 
accompanied by atrophy and disappearance of the epidermis of the part. The 
infiltrating cells are plasma cells, various kinds of lymphoid cells and large 
cells with single vesicular nuclei and a relatively large amount of cytoplasm 
in which are large numbers of the micro-organisms. These large cells, over 
extensive areas, are very numerous and constitute the principal part of the 
infiltration. They are regarded as proliferated endothélial cells ». 
Brooke 8 mentions the researches of Carter, Reihl, Leloir, Unna and 
Kuhn « who ail found it to be a chronic sero-fibrinous inflammation. There 
is a round-eelled infiltration of the skin and subcutaneous tissue. In the 
centre of the nodules this infiltration is so dense that the tissue éléments 
are entirely disintegrated . The lymphatic vessels are dilated and there is 
much oedema. Necrosis proceeds in the centre of the infiltrated tissue. These 
is cornification of the hair root-sheaths, preventing a subséquent now growth 
of hair at the pot. There is endothélial prolifération of the blood vessels, 
often leading to their entire oblitération ». 
Christopiiers and Stephens 9 in their latest édition do not deal with 
the subject nor does Daniels 10 . The English translation of Scheube's 
work 11 has a passage mtich like that in Brooke's book. 
« There is an infiltration of the skin and subcutaneous tissue with small 
round oval cells, multi-granulated and giant cells, and also a few leucocy¬ 
tes. In the centre of the nodules, over which the epithelium is attenuated, 
the infiltration is so dense that the tissue éléments are entirely disintegrated, 
while towards the periphery the cells form small centres, mostlv situated in 
the vicinity of blood vessels and lymphatics and sweat glands. The lympha¬ 
tic vessels and spaces are uncommonly wide and there is much oedema. In 
the centre of the infiltrated tissue small necrotic particles are enclosed, and 
this, when the sections are stained, exhibits large fibrinous contents ; the 
tissue otherwise also contains much fibrin (Unna). Those hairs that still 
exist are, according to Kuhn, partly broader, partly narrower, occasionally 
ravelled, and they always exhibit a granular appearance. The root sheaths 
