entamœba is E. tetragena, the phases outlined above will be 
seen. In some of the préparations from the last remove patho- 
logical forms of the trophozoites may be encountered. These ap- 
parently are identical with the budding and other forms descri- 
bed by Schaudinn and Craig and figured by Craig and Hart¬ 
mann. 
The peculiar pathological changes to be noted in the tropho¬ 
zoites, are as follows ; 
i° The appearance of buds of different sizes on the periphery 
of the trophozoites in question. These buds of the ectoplasm are 
sometimes elear and homogeneous and somestimes contain mas¬ 
ses of chromidia. Not infrequently a bud contains the nucléus. 
2° The extrusion of chromidia, nuclei and portions of cyto¬ 
plasm. Dislocation of the nucléus, it taking up an extreme pe- 
ripheral position in the cytoplasm, or attached by a slim pedicle 
and frequently appears to be stuek on to the periphery. Globu- 
lar portions of the cytoplasm (buds) are extruded. 
The staining qualities of the nucléus in these forms are always 
less sharp than in normal trophozoites and cysts nearby. 
If the entamœba is E. coli, trophozoites will be found vegeta- 
ting in the caecum or other part of the large bowel, and can 
be differentiated from E. tetragena. 
The writer believes that cases thought to be « histolytica » 
dysentery will résolve themselves into infections by E. tetragena. 
(From the Board of Health Laboratory, Ancon, Canal Zone). 
Mode d’action de la quinine sur Plasmodium 
vivax (var. magna du prof. Laveran) de la tierce 
et de la double-tierce bénigne de rechute 
Par J. RIEUX. 
Il est classique que la quinine fait disparaître du sang périphé¬ 
rique l’hématozoaire du paludisme. Mais le mode de disparition 
de cet agent n’est pas encore très connu. Nous avons entrepris 
l’étude de ce point de la question du paludisme à l’occasion de 
