318 Journal of Agricultural Research voi. xxix. No. i 
this efficacy is distinctly less than that 
of carbon tetrachloride, as would also 
be expected since the halogen concen¬ 
tration, to which the anthelmintic ef¬ 
ficacy is apparently due, is distinctly 
less in ethylene dichloride than in car¬ 
bon tetrachloride. 
TESTS OF FERROUS SULPHATE FOR 
REMOVING WHIPWORMS FROM 
HOGS 
PROTOCOLS 
Dog. No. 585; 8.5 kg.; 56.4 grains 
in 30 cc. of water with 5 grains of calo¬ 
mel; no worms passed in 5 days; post¬ 
mortem on fifth day, 2 whipworms, 1 
hookworm, 3 tapeworms. Entirely 
ineffective. 
Dog No. 586; 8.5 kg.; 42.3 grains 
in 22.5 cc. of water; no worms in 5 
days; post-mortem, on fifth day, 13 
whipworms. Entirely ineffective. 
Dog No. 587; 11 kg.; 28.2 grains 
in 15 cc. of water with 5 grains of calo¬ 
mel; no worms in 5 days; post¬ 
mortem, on fifth day, 24 whipworms, 2 
hookworms, 4 tapeworms. Entirely 
ineffective. 
Dog No. 588; 11 kg.; 32.9 grains 
in 17.5 cc. of water; no worms in 5 
days; post-mortem, on fifth day, 4 
whipworms. Entirely ineffective. 
Dog No. 589; 13 kg.; 87.8 grains in 
45 cc. of water with 5 grains of calomel; 
first day, 1 whipworm; second day, 2 
whipworms; third day, 1 whipworm; 
fourth and fifth days, negative; post¬ 
mortem, on fifth day, 109 whipworms. 
Treatment 4 per cent effective against 
whipworms. 
Dog No. 590; 12.5 kg.; 70.5 grains 
in 37.5 cc. of water; no worms in 5 days; 
post-mortem, on fifth day, 89 whip¬ 
worms and 3 tapeworms. Entirely 
ineffective. 
DISCUSSION 
It has been pointed out by Hall (10; 
12) that even feeble anthelmintics, 
such as ferrous sulphate, will occasion¬ 
ally remove whipworms from dogs; 
but, as noted above (p. 315), the efficacy 
of a drug in removing these worms 
depends on its entry into the cecum. 
This entry might be insured by the use 
of a drug of low toxicity and little 
irritant quality that could be given in 
repeated doses or in massive doses, as 
previously noted by the authors and as 
stated by Lambert (29 ). For repeated 
doses santonin seems the most satis¬ 
factory drug known at present. For 
bulky doses the latex of Ficus lauri- 
folia, a fig which grows in South and 
Central America, appears to be favored 
in human medicine. This has been 
used by physicians in the region in 
which it grows, and has been recom¬ 
mended by Berrio, Mouatt-Biggs, and 
others. It is given in the compara¬ 
tively large doses of 10 to 45 gm., and is 
said to be the best drug known for 
administration in this way against 
whipworms. 
Theoretically, ferrouss ulphate might 
prove to be of value in this connection, 
since its toxicity is low and its slow 
movement through the digestive tract 
might insure its entry into the cecum 
in a fair number of cases when given 
in rather large doses. The drug is 
often prescribed in veterinary medicine 
for worms in various animals, although 
its use is almost entirely on an empirical 
basis. The present experiments indi¬ 
cate that in doses of 28.2 to 87.7 grains 
to dogs weighing from 8.5 to 13 kg., it 
shows little efficacy against whipworms 
and can not be depended on to remove 
these worms in single doses. 
TESTS OF CHENOPODIUM INTRA¬ 
MUSCULARLY AND INTRAVE¬ 
NOUSLY FOR REMOVING WHIP¬ 
WORMS FROM DOGS 
PROTOCOLS 
Dog No. 549; 6 kg.; 0.5 cc. cheno- 
podium intramuscularly in large mus¬ 
cles of hind leg; no worms in 4 days. 
Treatment ineffective, as this animal 
showed whipworm eggs in feces. 
Dog No. 552; 9 kg.; 1 cc. cheno- 
podium intramuscularly in large mus¬ 
cles of hind leg; no worms in 4 days. 
Treatment ineffective, as this animal 
showed whipworm eggs in feces. 
Dog No. 609; 8 kg.; 1 cc. cheno- 
podium intravenously; no worms in 2 
days; animal dead second day; post¬ 
mortem showed 6 whipworms attached 
in cecum, 1 whipworm unattached in 
colon, 12 tapeworms (Dipylidium sp.). 
Treatment comparatively ineffective, 
assuming, as seems probable, that the 
whipworm unattached in the colon 
would have passed out in a day or so 
and that the treatment should pro¬ 
bably be credited with its removal. 
Dog No. 610; 7 kg.; 0.5 cc. intrave¬ 
nously; 1 whipworm the second day; 
some tapeworm fragments, but no 
heads, during 4 days; post-mortem, on 
fourth day, 14 whipworms, 5 hook¬ 
worms, and 28 tapeworms. Drug 7 
per cent effective against whipworms; 
entirely ineffective against hookworms 
and tapeworms. 
