Oct. 1, 1924 
Critical Tests of Miscellaneous Anthelmintics 
319 
DISCUSSION 
The idea of removing whipworms by 
means of intramuscular injections 
seems to have occurred first to Strong 
(4%), who administered to human 
patients thymol and chenopodium, 
each in sterile olive oil, without results 
in the form of'whipworms passed or 
. noticeable diminution in the number of 
eggs present in the feces. 
More recently Lambert {29) has 
reported tests on human patients of 
intramuscular and intravenous injec¬ 
tions of chenopodium. For his intra¬ 
muscular injections Lambert used in 
two cases a mixture of 60 cc. oil of 
chenopodium, 60 cc. of camphorated 
oil, and 4 grams of resorcin, giving 4 
cc. in one case and 10 cc. in another. 
After the dose of 4 cc. (equivalent to 
2 cc. of chenopodium), the patient 
passed 4 hookworms in the course of 
4 days; an anthelmintic by mouth 
removed 89 hookworms, 1 ascarid, and 
1 whipworm. After the dose of 10 cc. 
(equivalent to 5 cc. of chenopodium), 
the patient passed 2 hookworms and 1 
ascarid in the course of 3 days; an 
anthelmintic by mouth removed 155 
hookworms and 1 ascarid. After a dose 
of 3 cc. of undiluted chenopodium the 
patient passed 3 hookworms, 22 whip¬ 
worms, 9 pin worms; no anthelmintic 
was given by mouth, but hookworm 
eggs persisted in the feces after treat¬ 
ment. 
For intravenous injections Lambert 
used pure oil of chenopodium in doses 
of 2 cc. in one case and 1.5 cc. in two 
other cases. After the dose of 2 cc. the 
patient passed 11 whipworms and 882 
pinworms in the course of 3 days; 
chenopodium given by mouth removed 
33 hookworms and 1 whipworm. One 
patient given 1.5 cc. intravenously 
passed 19 whipworms and 2 ascarids 
in the course of 4 days; no anthelmintic 
was given by mouth, but fecal examina¬ 
tion showed hookworm eggs present in 
the feces. The other patient given 1.5 
cc. intravenously passed 30 whipworms 
and 2 ascarids in the course of 3 days; 
no anthelmintic was given by mouth, 
but fecal examination showed hook¬ 
worm eggs present in the feces. 
From Lambert’s experiments it 
appears that chenopodium intramus¬ 
cularly will remove some whipworms, 
ascarids, hookworms, and pinworms, be¬ 
ing apparently rather effective against 
whipworms in some cases, but not 
promising anything vaulable against 
the other worms named. Intrave¬ 
nously chenopodium removed whip¬ 
worms, ascarids, and pinworms, the 
« efficacy against whipworms being 
most evident, with the possibility that 
this treatment is fairly effective against 
ascarids and pinworms, although the 
evidence is not sufficient to warrant the 
idea that it is certainly as effective as 
other measures known to be less 
dangerous. 
In the present experiments intra¬ 
muscular injections of chenopodium 
made the animals lame and failed to 
remove whipworms. It does not there¬ 
fore appear to be a promising mode of 
treatment for removing whipworms 
from dogs. Intravenous injections 
apparently removed 1 whipworm from 
each of 2 dogs, leaving 6 and 14 worms, 
respectively. Judging from Lambert’s 
results a much higher efficacy might 
be obtained in individual cases, but the 
results in these two cases do not look 
promising, although intravenous injec¬ 
tions show a greater efficacy in remov¬ 
ing whipworms than intramuscular 
injections show. 
A low efficacy seems indicated in the 
case of dogs and a high efficacy in 
human patients, judging from the usual 
numbers present in man in the region 
involved. This method of treatment 
should be investigated further. Pos¬ 
sibly drugs more satisfactory than 
chenopodium could be found for intra¬ 
venous injection. In the human cases 
syncope followed the injections; and 
in one dog the syncope immediately 
after the injections was followed by 
general incoordination, pronounced 
sickness with decubitus, and death the 
second day. 
TESTS OF NOVARSENOBENZOL IN 
SOLUTION BY MOUTH, SUBCUTA¬ 
NEOUSLY AND INTRAVENOUSLY 
FOR WHIPWORMS IN DOGS 
PROTOCOLS 
Dog No. 612; 10.5 kg.; 0.6 gm. 
subcutaneously; no worms in 6 days; 
the dog died after 11 days; too badly 
decomposed to warrant post-mortem 
examination following negative results. 
Dog No. 613; 5 kg.; 0.15 gm. intra¬ 
venously; no worms in 2 days; 0.75 
gm. intravenously the third day; no 
worms in 4 days; post-mortem, on 
fourth day after second treatment, 
19 whipworms, 9 tapeworms. Wholly 
ineffective. 
Dog No. 615; 15 kg.; 0.45 gm. 
intravenously; no worms in 4 days; 
no post-mortem. Apparently wholly 
ineffective. 
Dog No. 616; 13 kg.; 0.3 gm. by 
mouth; no worms in 4 days; after 42 
days this dog (now weighing 18.5 kg.) 
