*Dct. 1,1924 
Critical Tests of Miscellaneous Anthelmintics 
321 
’post-mortem, on fourth day, 62 tape¬ 
worms, 12 hookworms, 2 whipworms. 
Drug 9 per cent effective against tape¬ 
worms, entirely ineffective against 
hookworms and whipworms. 
DISCUSSION 
Since discoverers of especially effec¬ 
tive drugs have the alternative of pub¬ 
lishing their findings for general use or 
marketing their products for profit, 
there is always the possibility that 
proprietary remedies may at times be 
found more effective than the drugs 
generally known and used. For this 
reason the writers occasionally test 
proprietary anthelmintics. The pro¬ 
prietary preparation under considera¬ 
tion here is advertised as a safe and 
effective anthelmintic for tapeworms 
in dogs. A test indicates that it may 
fail to remove more than 9 per cent of 
the tapeworms from a dog. This is not 
surprising, as drugs intended to re¬ 
move tapeworms do not show in a 
general way the dependable efficacy of 
the best drugs for the removal of 
nematodes. Thus occasional failures 
to get tapeworms occur with such 
standard taeniacides as male fern, 
kamala, areca nut, arecoline hydro¬ 
bromide, etc. The proprietary in ques¬ 
tion is probably effective in many cases. 
'CHE NOPODIUM AND MAGNESIUM 
SULPHATE, SIMULTANEOUSLY 
ADMINISTERED, TESTED FOR 
TOXIC EFFECTS AND EFFECTS 
ON WORMS IN DOGS 
PROTOCOLS 
Dog No. 615; 16 kg.; chenopodium at 
the lethal dose rate, 0.6 cc. per kilo¬ 
gram (9.6 cc.), by stomach tube, fol¬ 
lowed immediately by 90 cc. of a satu¬ 
rated solution of magnesium sulphate; 
fecal examination negative and no 
worms passed in 4 days; the animal 
continued in good health and was not 
killed; animal negative on preliminary 
fecal examination. 
Dog No. 634; 8 kg.; chenopodium at 
the lethal dose rate, 0.6 cc. per kilo¬ 
gram (4.8 cc.), by stomach tube, fol¬ 
lowed immediately by 60 cc. (2 ounces) 
of a 50 per cent concentration of mag¬ 
nesium sulphate solution; fecal exam¬ 
ination negative and no worms passed 
in 4 days; post-mortem examination on 
fourth day negative for worms; the 
only lesion was a slight inflammation in 
places in the small intestine. 
Dog No. 635; 11 kg.; chenopodium 
*at the lethal dose rate, 0.6 cc. per kilo¬ 
gram (6.6 cc.), by stomach tube, fol¬ 
lowed immediately by 60 cc. (2 ounces) 
of a 50 per cent concentration of mag¬ 
nesium sulphate solution; dog vomited 
in a few minutes and died in about 12 
hours; no worms passed; post-mortem 
showed 5 whipworms. This dog’s 
stomach had slightly inflamed areas; 
the small intestine showed excessive 
catarrhal enteritis, and had a marked 
odor of chenopodium; the cecum and 
large intestine were normal in appear¬ 
ance, though there was catarrhal ma¬ 
terial in the lumen of the large intestine, 
possibly from the small intestine; the 
lungs were much congested. 
Dog No. 650; 8 kg.; chenopodium in 
double the minimum lethal dose rate 
of 0.5 cc. per kilogram, or 1 cc. per kilo¬ 
gram (8 cc.), by stomach tube, followed 
immediately by 60 cc. (2 ounces) of a 
50 per cent concentration of magnesium 
sulphate solution; fecal examination 
negative, no worms passed in 4 days, 
none present post-mortem on fourth 
day; all organs apparently normal 
post-mortem. 
Dog No. 651; 11 kg.; chenopodium 
at the therapeutic dose rate for ascarids, 
or 0.1 cc. per kilogram (1.1 cc.), by 
stomach tube, followed immediately 
by 60 cc. (2 ounces) of a 50 per cent 
concentration of magnesium sulphate 
solution; 1 ascarid the first day; no 
worms the next 3 days; post-mortem, 
on fourth day, 1 ascarid. Efficacy 
against ascarids, 50 per cent. 
Dog No. 636 ; 8 kg.; chenopodium 
at the therapeutic dose rate for as¬ 
carids, or 0.1 cc. per kilogram (0.8 cc.), 
by stomach tube, followed immediately 
by 60 cc. (2 ounces) of a 50 per cent 
concentration of magnesium sulphate 
solution; 14 ascarids the first day; no 
worms the next 3 days; post-mortem, 
on fourth day, 3 whipworms, 4 tape¬ 
worms. Treatment 100 per cent 
effective against ascarids; entirely 
ineffective against whipworms and 
tapeworms. 
Dog No. 648; 7 kg.; chenopodium at 
the therapeutic dose rate for ascarids, 
or 0.1 cc. per kilogram (0.7 cc.), by 
stomach tube, followed immediately 
by 60 cc. (2 ounces) of a 50 per cent 
concentration of magnesium sulphate 
solution; 1 hookworm the second day; 
no worms the first, third and fourth 
days; post-mortem, on fourth day, 
54 whipworms. Treatment 100 per 
cent effective against hookworms; en¬ 
tirely ineffective against whipworms. 
Dog 636 was killed by the intraperi- 
toneal injection of 150 cc. of a saturated 
solution of magnesium sulphate; the 
animal lay down, became unconscious, 
and died in about 10 minutes. The 
99184—25f-2 
