326 
Journal of Agricultural Research 
Vol. XXIX, No. 7 
solutions by mouth in rare instances. 
The use of intraperitoneal solutions of 
magnesium sulphate to kill dogs has 
recently been advocated, and the 
writers have found it a comparatively 
rapid and painless method, the most 
striking post-mortem lesions consist¬ 
ing in a vascular engorgement of the 
blood vessels of the viscera of the 
abdominal cavity. 
In view of the bad effects on these 
sheep, the remaining six were each 
given 6 cc. of carbon tetrachloride 
with two No. 10 capsules of pure 
magnesium sulphate. Some of these 
animals appeared quite uncomfortable 
for a few minutes after dosing and 
showed a rapid respiration. 
In further experiments some changes 
were made in the number of sheep and 
the individuals used in this flock, and 
the dose adopted for routine use was 
5 cc. of carbon tetrachloride in a hard 
capsule, No. 13, holding a little more 
than 5 cc., together with dry mag¬ 
nesium sulphate in air equivalent 
bulk, about 5 cc., in the same-sized 
capsule. This treatment has con¬ 
tinued now for 5 months since the 
first treatment, a total of 6 treatments, 
and fecal examinations show that it is 
of value in controlling infestations with 
various worms. It is planned to con¬ 
tinue such monthly treatment for 
about a year, at the end of which time 
post-mortem examinations, together 
with the tables of weights for the 
period of the experiment, will show 
something more definite as to the 
value of the treatment. 
TEST OF ARSENIC FOR REMOVING 
WORMS FROM HORSES 
PROTOCOL 
Horse No. 233, weighing 735 lbs.> 
was given the following preparation: 
Arsenic, 30 grains; calomel, 60 grains; 
animal charcoal, 80 grains. This was ad¬ 
ministered in a hard gelatine capsule in 
the morning after fasting the animal from 
noon of the previous day, and was 
followed by a quart of water ad¬ 
ministered as a drench, with no feed¬ 
ing until 3 hours after treatment. The 
manure was examined daily for the 
next 6 days and no worms were found. 
The animal was then given copper 
sulphate as noted in the next experi¬ 
ment and, as noted in that experiment, 
was found to have numerous worms 
(Habronema spp., Strongylus sp., and 
cylicostomes) present post-mortem. 
The conclusions are similar for both 
experiments. 
DISCUSSION 
Although arsenic and combinations 
of arsenic and copper sulphate are effec¬ 
tive in controlling stomach worms in 
sheep and goats, and the combination 
is quite effective in controlling tape¬ 
worms, hookworms, and to some extent 
nodular worms in these animals, arsenic 
in the dose given and as administered 
does not appear to be promising as 
an anthelmintic for worms in horses, 
although it has long been recommended 
and used for this purpose. Winslow 
(43) states: “Large single doses of 
arsenious acid (3ss) are sometimes given 
with calomel (3i) and aloes (5iv) in a 
ball to horses to kill roundworms.” 
This is the dose of arsenic tested here. 
As the horse used had no ascarids, no 
conclusions are possible on the value of 
arsenic against these worms in the 
horse; but other tests with arsenic sug¬ 
gest that carbon bisulphide and carbon 
tetrachloride, and perhaps chenopo- 
dium, are superior to arsenic for this 
purpose. 
TEST OF COPPER SULPHATE FOR 
REMOVING WORMS FROM HORSES 
PROTOCOL 
Horse No. 233, weighing 735 pounds, 
was given 8 gm. of copper sulphate in 
192 cc. of distilled water, the solution 
being administered as a drench,. This 
was given in the morning after fasting 
the animal from noon of the previous 
day. The horse was not fed until an 
hour after treatment. The manure was 
examined daily for the next 9 days and no 
worms were found. The animal was 
killed on the ninth day and worms 
collected from it as follows: Numerous 
specimens of Habronema spp.; 221 
Strongylus sp. collected and counted 
and an additional 104 estimated as 
present, or a total of 325 Strongylus 
sp.; 122 cylicostomes collected and 
counted and an additional 1,088 esti¬ 
mated as present, or a total of 1,210 
cylicostomes. 
DISCUSSION 
The treatment must be regarded as 
ineffective, although it can not be con¬ 
cluded that some worms of the genus 
Habronema might not have been de¬ 
stroyed by the copper sulphate, for, as 
pointed out above, when worms in the 
stomach are killed by any anthelmintic, 
only the worms near the pylorus may be 
expected to escape digestion. In the 
long journey through the large intestine 
