Oct. 1, 1924 
Critical Tests of Miscellaneous Anthelmintics 
331 
Ethylene dichloride proved only 
slightly effective against hookworms 
when given at a dose rate equivalent 
to the therapeutic dose rate for carbon 
tetrachloride. 
Ferrous sulphate in large doses 
showed very little efficacy against 
whipworms and is evidently not de¬ 
pendably effective in single doses for 
removing these worms. 
Chenopodium intramuscularly failed 
to remove whipworms from two in¬ 
fested dogs. Intravenously it removed 
only one whipworm from each of two 
infested dogs, showing that the drug 
has some anthelmintic action when 
thus given, as Lambert had found, but 
also showing a lack of dependable action 
even in dangerous doses. 
Novarsenobenzol subcutaneously 
failed to remove any whipworms from 
the one dog on which the drug was thus 
tested. Intravenously in single dose 
to one dog and in two doses to another 
it failed to remove any whipworms. 
Tartar emetic in single dose intra¬ 
venously to three dogs failed to remove 
any whipworms. 
A proprietary remedy for tapeworm 
in dogs removed only 9 per cent of 
the tapeworms present. 
Magnesium sulphate simultaneously 
administered with lethal doses of cheno¬ 
podium to dogs protected them from 
the toxic effects of the chenopodium, 
three out of four animals surviving the 
dose. Hall has shown that castor oil 
or calomel will protect dogs against the 
toxic effects of lethal doses of such 
drugs as chenopodium and male fern, 
from which it appears that the protec¬ 
tive action of magnesium sulphate is 
due not only to its salt action but also 
to its purely purgative action. Our 
experiments also show that magnesium 
sulphate simultaneously administered 
with therapeutic doses of chenopodium 
does not diminish the efficacy of the 
chenopodium against ascarids, and 
suggest that the same is true as regards 
effect on hookworms. The writers 
have previously shown that magnes¬ 
ium sulphate simultaneously adminis¬ 
tered with carbon tetrachloride does not 
diminish the efficacy of this drug 
against hookworms. 
Carbon tetrachloride, given with 
magnesium sulphate, will remove hook¬ 
worms and nodular worms from mon¬ 
keys, but the exact efficacy is unknown. 
Carbon tetrachloride given to sheep 
in doses of 10 cc. followed immediately 
by 128 gm. of magnesium sulphate 
shows 100 per cent efficacy against 
stomach worms, nodular worms, and 
small trichostrongyles. Previous evi¬ 
dence from other experiments indicates 
that it is also 100 per cent effective 
against hookworms. When thus ad¬ 
ministered with magnesium sulphate 
there is a marked increase in efficacy 
against tapeworms, this treatment 
removing 33 per cent of these worms 
instead of being almost entirely in¬ 
effective. A flock of sheep is now being 
treated with monthly doses of 5 cc. of 
carbon tetrachloride and an equivalent 
bulk of dry magnesium sulphate to 
determine the value of such repeated 
treatments in controlling worms in 
sheep. 
Arsenic in the 30-grain dose ordi¬ 
narily recommended for worms in 
horses apparently failed entirely to 
remove any stomach worms, palisade 
worms, or cylicostomes from a horse. 
Copper sulphate (8 gm.) in solution 
apparently failed entirely to remove 
any stomach worms, palisade worms, 
or cylicostomes from a horse. 
Novarsenobenzol intravenously for 
4 days for a total amount of 14.4 gm. 
failed to kill strongyles (Strongylus 
vulgaris) in a verminous aneurism in a 
horse. 
LITERATURE CITED 
(1) Alessandrini, G. 
1915. LE MALATTIE DA PARASSITI ANIMALI NEGLI 
eserciti combattenti. Policlinico (sez. prat.) 
22:822-827. 
(2) Allen, J. A. 
1922. THE EFFICIENCY OF CARBON TETRACHLORID 
AGAINST HOOKWORMS IN THE SILVER BLACK 
fox. Jour. Amer. Vet. Assoc, (n. s. 14) 61:31— 
37, illus. 
(3) Berard, L., and Vignard, P. 
1916. APPENDICITIS AND INTESTINAL PARASITES. 
Med. Fortnightly & Lab. News 48: 339-345. 
(4) Caius, J. F., and Mhaskar, K. S. 
1920. THE CORRELATION BETWEEN THE CHEMICAL 
COMPOSITION OF ANTHELMINTICS AND THEIR 
THERAPEUTIC VALUES IN CONNECTION WITH 
THE HOOKWORM INQUIRY IN THE MADRAS 
presidency, viii. chloroform. Indian Jour. 
Med. Research 8:379-383. 
(5) - 
1921. AN INQUIRY INTO THE CORRELATION BE¬ 
TWEEN THE CHEMICAL COMPOSITION OF ANTHEL¬ 
MINTICS AND THEIR THERAPEUTIC VALUES IN 
CONNECTION WITH THE HOOKWORM INQUIRY IN 
the madras presidency. Indian Jour. Med. 
Research 8:737-740. 
( 6 ) - 
1922. THE CORRELATION BETWEEN THE CHEMICAL 
COMPOSITION OF ANTHELMINTICS AND THEIR 
THERAPEUTIC VALUES IN CONNECTION WITH 
THE HOOKWORM INQUIRY IN THE MADRAS 
PRESIDENCY. XVI. PROPENYL PHENOLS. In¬ 
dian Jour. Med. Research 10:343-360. 
(7) - 
1923. THE CORRELATION BETWEEN THE CHEMICAL 
COMPOSITION OF ANTHELMINTICS AND THEIR 
THERAPEUTIC VALUES IN CONNECTION WITH 
THE HOOKWORM INQUIRY IN THE MADRAS 
PRESIDENCY. XXII. SUMMARY AND CONCLU¬ 
SIONS. Indian Jour. Med. Research 11: 371-375. 
(8) Docherty, J. F., and Nicholls, L. 
1923. REPORT OF THREE AUTOPSIES FOLLOWING 
CARBON TETRACHLORIDE TREATMENT. Brit. 
Med. Jour. 1923 : 753. 
(9) Freeborn, S. 
1923. THE CONTROL OF THE SUCKERED ROUND- 
worms of poultry. Cornell Vet. 13 : 223-231. 
