Apr. 12, 1924 
Pharmacology of Gossypol 
193 
Table I. — Metabolism of cat No. 30 undergoing gossypol poisoning 
DIET: 100 GM. MEAT, 2 GM. BUTTERFAT, 2 GM. SKIM MILK POWDER 
Nitrogen daily 
Date 
1920 
Weight 
Grams 
Bone ash 
fed 
Grains 
Fed 
Grams 
Urine a 
Grams 
Feces 
Gram 
Balance 
Gram 
Gossypol administered 
Oct. 26-31 
Nov. 1-4.. 
5— 
6-7 c, 
8 ... 
9.. . 
10 .. . 
lie.. 
12 ... 
13 «.. 
14 c.. 
15.. . 
16.. . 
17.. . 
18.. . 
1,820 
1,855 
1,890 
1,985 
1,890 
1,795 
1,825 
1,825 
1,830 
1,820 
1,825 
1,880 
1,865 
1,855 
1,865 
1,850 
1,860 
} 
2 
2 
2 
4 
4 
4 
4 
4 
4 
4 
4 
4 
4 
4 
4 
3.42 
0.077 
Fore-period. 
3.42 
& 2.01 
3.33 
3.33 
3.33 
3. 33 
3.33 
3. 33 
3.33 
3.33 
3.33 
3.33 
3.33 
3. 33 
2.641 
2.697 
2.725 
2.599 
2.599 
3.117 
3.117 
3.302 
3.302 
3. 397 
3.397 
.312 
.055 
. 192 
.192 
+0.497 
.143 
+.490 
.143 
+.462 
.206 
+. 525 
.206 
+. 525 
.206 
+.007 
.206 
+. 007 
Lost. 
...do. 
—do. 
—do. 
►90 mgm. daily. 
►None. 
45 mgm. daily. 
DIET: 75 GM. MEAT, 2 GM. BUTTERFAT, 2 GM. SKIM MILK POWDER 
Dec. 11. 
1,843 
2 
2.617 
2.640 
0.061 
-0.084 
12. 
2 
2. 617 
2.640 
.061 
-.084 
13. 
1,835 
2 
2.617 
2.640 
.061 
-.084 
•Fore-period. 
14. 
2 
2.617 
2. 515 
.061 
+. 041 
+. 041 
15_. 
1,840 
2 
2.617 
2.515 
.061 
16. 
1,840 
2 
2. 617 
2.690 
. 182 
-. 255 
17 c. 
1,875 
2 
2.617 
2.599 
. 182 
-.164 
18. 
2 
2.617 
2.802 
. 182 
—.367 
45 mgm. in butterfat 
. and milk powder 
daily. 
19. 
2 
2.617 
2.802 
. 182 
—.490 
20 c. 
1,840 
1,850 
1,820 
1,780 
1,780 
1,765 
2 
2.617 
3.068 
.245 
—. 698 
21. 
2 
2.617 
3.068 
.245 
—.696 
22. 
2 
2.617 
3.068 
.245 
—.696 
23 c. 
2 
2.617 
3.068 
.245 
-.696 
24. 
1 
1921 
Jan. 4_ 
1 2 
2.617 
2.456 
.1414 
+.020 
After-period. 
°No albuminuria. 
& Net quantity fed after animal vomited, 
c 1 gm. of charcoal fed. 
Table II. — Toxicity of gossypol 
Animals used 
Injected intraperitoneally in 
peanut oil 
Animals used 
Injected intravenously as 
sodium salt 
Usually 
survived 
Average 
lethal 
Certain 
lethal 
Usually 
survived 
Average 
lethal 
Certain 
lethal 
5 rabbits.. 
2 cats__ 
Mgm. 
per kgm. 
5 
40-80 
20 
Mgm. 
per kgm. 
10 
Mgm. 
per kgm. 
20 
10 rabbits.. 
9 cats__ 
Mgm. 
per kgm. 
50 
35 
Mgm. 
per kgm. 
35-40 
Mgm. 
per kgm. 
50- 
75 
50+ 
20 rats.. 
30-35 
50 
8 rats.. 
40-50 
