332 
Journal of Agricultural Research 
Vol. XXVIII, No. 4 
A dose rate of 0.1 cc. per kilo was given in hard gelatine capsules to the follow¬ 
ing: 
Fox No. 201 .—Weight 5.24 kilos; passed no worms. Post-mortem fourth day, 12 hookworms, 2 ascarids, 
and 1 tapeworm; 0 per cent vs. hookworms, ascarids, and tapeworms. No apparent symptoms or gross 
lesions due to the treatment. 
Fox No. 209. —Weight 2.5 kilos; 19 hookworms first day, 3 hookworms second day; retained no worms; 
100 per cent vs. hookworms. Post-mortem fourth day; liver slightly swollen, with tissues bulging slightly 
on section; region of congestion between cortex and medulla of kidneys; slight congestion of mucosa of small 
intestine. 
A dose rate of 0.2 cc. per kilo was given in hard gelatine capsules to the follow¬ 
ing: 
Fox No. 208. —Weight 5.45 kilos; passed 18 hookworms first day; retained no worms; 100 per cent vs. hook¬ 
worms; no apparent symptoms or gross lesions. 
Fox No. 204. —Weight 6.36 kilos; passed 7 hookworms first day. Post-mortem fourth day; 1 hookworm 
and 2 ascarids; 88 per cent vs. hookworms and 0 per cent vs. ascarids; no apparent symptoms or macroscopic 
lesions due to the treatment. 
Fox No. 786. —Weight 4.1 kilos; 4 hookworms and 21 ascarids first day; 3 hookworms second day; 2 ascarids 
third day; killed fourth day and 1 ascarid found; 100 per cent vs. hookworms and 92 per cent vs. ascarids. 
No apparent symptoms or gross lesions. 
Fox No. 787.— Weight 3.4 kilos; 11 hookworms first day; 1 hookworm second day; retained no worms; 
100 per cent vs. hookworms; no apparent symptoms. Post-mortem fourth day; slight congestion of mucosa 
of duodenum; liver darker in color than normal, with tissues friable and bulging slightly on section; spleen- 
swollen. 
Fox No. 788. —Weight 3.2 kilos; one ascarid first day; killed fourth day and no worms recovered. Post¬ 
mortem: Slight congestion of the mucosa of the posterior region of the small intestine; liver light in color 
and tissues friable; spleen dark and swollen. 
A dose rate of 0.25 cc. per kilo was given in soft elastic globules to the fol¬ 
lowing: 
Fox No. 882. —Weight 4.3 kilos; one hookworm first day; four hookworms second day; killed third day 
and no worms retained; 100 per cent vs. hookworms; no apparent symptoms. Post-mortem: Tissues of 
kidney lighter in color than normal and bulging slightly on section; liver slightly darker in color than 
normal; mucosa of stomach and duodenum congested; wall of duodenum thickened. 
Fox No. 884 . —Weight 4.1 kilos; 3 ascarids and 8 intestinal flukes first day; 1 hookworm second day; 
killed third day and 2 hookworms present; 33 per cent vs. hookworms and 100 per cent vs. ascarids and 
intestinal flukes. No apparent symptoms or gross lesions due to the drug. 
Fox No. 856.— Weight 1.86 kilos; age 3 months; 43 hookworms and 24 ascarids first day; 7 hook¬ 
worms and 1 ascarid second day; killed third day and 3 hookworms and 1 ascarid recovered; 94.3 per • 
cent vs. hookworms and 96.1 per cent vs. ascarids. Post-mortem: Liver greatly enlarged and darker in 
color than normal; tissues of kidney bulged slightly on section; region of congestion between cortex and 
medulla of kidney; mucosa of duodenum slightly congested; wall of duodenum thickened. 
A dose rate of 0.3 cc. per kilo was given either in soft elastic globules or hard 
gelatine capsules to the following: 
Fox No. 88. —Weight 2.38 kilos; age, ZH months; subject to a disease characterized by convulsions; dose 
given in hard gelatine capsules and followed in 4 hours by 5 cc. of castor oil in capsules; 290 hookworms 
(280 Uncinaria stenocephala and 10 Ancylostoma caninum) first day: Fifth day convulsions reappeared and 
animal died; retained three hookworms; 99 per cent vs. hookworms. Post-mortem: Liver and kidneys 
congested; brain edematous; petechiae and ecchymosis of small intestine; ecchymotic and suggulation 
hemorrhages of the cecum and colon; doubtful if carbon tetraehlorid was a factor in the cause of death. 
Fox No. 197. —Weight 3.4 kilos; drug in hard gelatine capsule; passed 13 hookworms first day; killed 
fourth day and no worms present; no apparent symptoms. Post-mortem: Liver slightly enlarged; 
mucosa of stomach slightly congested; few small scattered foci of necrosis of the mucosa of stomach; 
mucosa of small intestine slightly congested. 
Fox No. 198— Weight 3.63 kilos; drug in hard gelatine capsule; passed 13 hookworms and 1 ascarid 
first day; killed fourth day and no worms present; 100 per cent vs. hookworms and ascarids; no apparent 
symptoms or gross lesions due to treatment. 
Fox No. 200— Weight 2.7 kilos; drug in hard gelatine capsule; no worms found in feces or upon autopsy 
examination; no conclusions as to efficacy; no apparent symptoms. Post-mortem fourth day: Slight 
congestion of the kidneys and mucosa of duodenum. 
Fox No. 888. —Weight 3.3 kilos; drug in soft elastic globule; passed two hookworms and two intestinal 
flukes first day; killed third day and no worms present; 100 per cent vs. hookworms and intestinal flukes; 
no apparent symptoms; mucosa of stomach and small intestine slightly congested. 
