Apr. 26,1924 Carbon Tetrachlorid in the Treatment of Foxes 333 
Fox No. 885. —Weight 3.1 kilos; drug in soft elastic globule; passed two hookworms first day; no worms 
present when killed third day; 100 per cent vs. hookworms; no apparent symptoms. Post-mortem: 
Liver darker in color than normal and blood oozed on section; tissues of kidney bulged slightly on sec¬ 
tion; mucosa of duodenum congested and wall thickened; Peyer’s patches prominent. 
Fox No. 357. —Weight 1.7 kilo; age 3 months; drug in soft elastic globule; 10 hookworms and 15 ascarids 
first day; 1 ascarid second day; killed third day and 4 hookworms found; 71.4 per cent vs. hookworms and 
100 per cent vs. ascarids; no apparent symptoms. Post-mortem: Liver icteric and light in color with tissues 
friable; mucosa of small intestine slightly congested. 
Fox No. 798. —Weight 0.68 kilo; age 34 days; length of fast not known, because this unweaned pup was 
removed from vixen and treated 1 hour later; drug in soft elastic globule; passed 15 ascarids first-day; 
died second day after treatment; no worms present on autopsy; 100 per cent vs. ascarids, symptoms of 
distress, lassitude, weakness, anorexia, and marked constipation became apparent 20 hours after treatment. 
Constipated feces were reddish in color. Post-mortem: Liver light in color and icteric; lobules of liver 
distinctly visible, being yellow at periphery and a bright red at center; suggulation hemorrhages of the 
endocardium of left ventricle; pericardium contained an excess of fluid; mesenteric lymph glands enlarged 
and edematous, inflammation of the mucosa of jejunum and ileum, contents of large intestine and posterior 
region of small intestine constipated and hemorrhagic. 
Fox No. 793. —Weight 0.8 kilo; age 35 days; length of fast not known because this unweaned pup was 
removed from its vixen and treated 1 hour later; drug given in soft elastic globule; passed 14 ascarids 
first day; died two days after treatment and 1 ascarid recovered; 93 per cent vs. ascarids; constipation, 
distress, lassitude, and anorexia became apparent day after treatment; feces passed with worms were 
hemorrhagic. Post-mortem: Suggulation hemorrhages of the endocardium of the left ventricle; ecchymo- 
tic hemorrhages of the lungs; liver light in color and icteric; lobules of liver distinctly visible, being yellow 
at the periphery and bright red at the center; stomach catarrhal; small intestine inflamed, with evidence 
of hemorrhage into lumen of posterior region; contents of cecum and colon constipated and hemorrhagic. 
A dose rate of 0.35 cc. per kilo was given in soft elastic globules to the following: 
Fox No. 848 . —Weight 2.86 kilos; 17 hookworms first day; killed second day and no worms retained; 100 
per cent vs. ascarids; no apparent symptoms or gross lesions due to the drug. 
Fox No. 855— Weight 1.4 kilos; age 3 months; 74 hookworms and 36 ascarids first day; 1 ascarid third 
day; killed fourth day; 1 ascarid retained; 100 per cent vs. hookworms and 97 per cent vs. ascarids; no 
apparent symptoms. Post mortem: Liver light in color and icteric, with tissues friable; pericardium 
contained a slight excess of fluid; mucosa of duodenum slightly congested. 
A dose rate of 0.4 cc. per kilo was given in soft elastic globules to the following: 
Fox No. 728. —Weight 4.54 kilos; affected with sarcoptic mange, but in good physical condition other¬ 
wise; 12 hookworms first day; killed fourth day; no worms retained; 100 per cent vs. hookworms; no ap¬ 
parent symptoms. Post-mortem: Mucosa of stomach and small intestine slightly congested; wall of small 
intestine thickened; region of congestion between cortex and medulla of kidneys. 
Fox No. 781— Weight 4.1 kilos; no feces passed in first two days; one hookworm and two ascarids third 
day; killed fourth day and no intestinal worms present; 100 per cent vs. hookworms and ascarids; no apparent 
symptoms. Post-mortem: Congestion of liver and pancreas; kidneys darker in color than normal, with 
region of congestion between cortex and medulla; mucosa of small intestine congested; considerable mucus 
and fibrin adhered to mucosa of small intestines; heart muscle pale. 
A dose rate of 0.45 cc. per kilo was given in soft elastic globules to the following: 
Fox No. 729— Weight 3.64 kilos; affected with sarcoptic mange, but apparently in good physical condi¬ 
tion otherwise; 18 hookworms first day; 8 hookworms second day; killed third day and 1 hookworm found; 
96 per cent vs. hookworms; no apparent symptoms. Post-mortem: Mucosa of stomach and small intestine 
slightly congested, kidneys darker in color than normal, with region of congestion between cortex and 
medulla. 
Fox No. 780. —Weight 3.7 kilos; affected with sarcoptic mange, but apparently in good condition other¬ 
wise; 169 hookworms, 1 ascarid, and 2 immature Physaloptera first day; killed third day, and no worms 
retained; 100 per cent vs. hookworms and ascarids; and probably 100 per cent vs. Physaloptera; no apparent 
symptoms. Post-mortem: Liver and kidneys darker in color than normal; region of congestion between 
cortex and medulla of kidney; wall of small intestine thicker than normal. 
A dose rate of 0.5 cc. per kilo was given in soft elastic globules to the following: 
Fox No. 825. —Weight 3.8 kilos; four hookworms and one ascarid first day; killed fifth day and no worms 
found; 100 per cent vs. hookworms and ascarids; no apparent symptoms. Post-mortem: Liver darker 
in color than normal and swollen, with blood oozing on section; slight congestion of mucosa of small 
intestine. 
Fox No. 600. —Weight 3 kilos; age 4 months; 31 hookworms and 70 ascarids first day; retained 2 asca¬ 
rids; 100 per cent vs. hookworms and 97 per cent vs. ascarids. Animal became constipated and died 30 
hours after treatment. Weakness and restlessness became apparent an hour or so before death. Post¬ 
mortem findings were: Abdominal cavity filled with dark unclotted blood, which turned bright red upon 
