334 
Journal of Agricultural Research 
Vol. XXVIII, No. 4 
exposure to air; this blood failed to clot upon standing over 24 hours; suggulation hemorrhages of the en¬ 
docardium of the left ventricle, the lungs were pale and anemic with a few foci of ecchymosis present; the 
liver was icteric and its tissues friable; lobules of liver distinctly visible, being bright red at the center 
and yellow at the periphery; pancreas congested; tissues of the mesenteric lymph glands were hemorrha¬ 
gic; the mesentery and diaphragm showed suggulation hemorrhages; mucosa of stomach and small 
intestine congested; wall of small intestine thickened; mucus and shreds of fibrin adhered to mucosa of th e 
posterior half of the small intestine. 
A dose of 0.6 cc. per kilo was given either in hard gelatine capsules or soft 
elastic globules to the following: 
Fox No. 202 .—Weight 4.3 kilos; dose in hard gelatine capsules; collapse and cessation of respiration oc¬ 
curred when the drug was inhaled as a result of one of the capsules dissolving in the mouth before being swal¬ 
lowed; artificial respiration performed and the animal recovered; manifested anorexia and constipation 
for two days; no worms found in feces or on autopsy examination; no conclusions as to efficacy; killed 
fifth day. Post-mortem: Liver enlarged; region of congestion between cortex and medulla of kidneys; 
mucosa of stomach and small intestines slightly congested. 
Fox No. 205 .—Weight 5.45 kilos; dose in hard gelatine capsules; six hookworms first day; killed fifth day,' 
few larval ascarids present which apparently reached the intestines after treatment; 100 per cent vs. hook¬ 
worms; no apparent symptoms. Post-mortem: Liver congested and tissues friable; region of congestion 
between cortex and medulla of kidneys; moderate congestion of mucosa of small intestine. 
Fox No. S2S .—Weight 3 kilos; dose in soft elastic globules; two hookworms first day; killed fifth day and 
no worms present; 100 per cent vs. hookworms; fed 2 hours after dosing and vomited 1 hour later. Post¬ 
mortem: Liver dark in color and several irregular white areas (apparently areas of necrosis) present on 
surface and in parenchyma; tissues of liver friable; tissues of kidney bulged slightly on section; mucosa 
of small intestine slightly congested and wall thickened. 
Fox No. S26 .—Weight 3.5 kilos; dose in soft elastic globules; 11 hookworms first day; killed fifth day 
and no worms present; 100 per cent vs. hookworms; no apparent symptoms. Post-mortem: Liver dark 
in color with tissues friable and blood oozing on section, tissues of kidney bulged slightly on section; pancreas 
congested and a few petechiae present; mucosa of duodenum greatly congested. 
DISCUSSION 
The anthelmintic efficiency of the various dose rates of carbon tetrachlorid 
used in the above experiments may be summarized as follows: 
At 0.1 cc. per kilo.— In hard gelatine capsules given to two foxes, this dose 
removed 22 hookworms and left 12, an efficacy of 64.7 per cent; removed no 
ascarids and left 2, an efficacy of 0 per cent; removed no tapeworms and left 1, 
an efficacy of 0 per cent. 
At 0.2 cc. per kilo.— In hard gelatine capsules given to five foxes, this dose 
removed 44 hookworms and left 1, an efficacy of 97.7 per cent; removed 24 
ascarids and left 3, an efficacy of 89 per cent. 
At 0.25 cc. per kilo.— In soft elastic globules given to three foxes, this dose re¬ 
moved 56 hookworms and left 5, an efficacy of 91.8 per cent; removed 28 ascarids 
and left 1, an efficacy of 96.5 per cent; removed 8 intestinal flukes and left none, 
an efficacy of 100 per cent. 
At 0.3 cc. per kilo.— In hard gelatine capsules or soft elastic globules given 
to nine foxes, this dose removed 330 hookworms and left 7, an efficacy of 97.9 per 
cent; removed 46 ascarids and left 1, an efficacy of 97.8 per cent; removed 2 
intestinal flukes and left none, an efficacy of 100 per cent. Administered in 
hard gelatine capsules to four foxes, this dose removed 316 hookworms and 
left 3, an efficacy of 99 per cent; removed 1 ascarid and left none, an efficacy of 
100 per cent. Given in soft elastic globules to five foxes, this dose removed 14 
hookworms and left 4, an efficacy of 77.7 per cent; removed 45 ascarids and left 
1, an efficacy of 97.8 per cent; removed 2 intestinal flukes and left none, an ef¬ 
ficacy of 100 per cent. 
At 0.35 cc. per kilo.— In soft elastic globules given to two foxes, this dose 
removed 91 hookworms and left none, an efficacy of 100 per cent; removed 37 
ascarids and left 1, an efficacy of 97.3 per cent. 
At 0.4 cc. per kilo.— In soft elastic globules given to two foxes, this dose re¬ 
moved 13 hookworms and left none, an efficacy of 100 per cent; removed 2 
ascarids and left none, an efficacy of 100 per cent. 
