CONTENTS 
PAGE 
Introduction . 5 
Historical Account of the Early Occurrence of Trembles and Milksickness.. 6 
The Cause of Trembles and Milksickness.•. 9 
a. Mineral Poison Theory . 9 
b. Microbic Theory ... 12 
c. Poisonous Plant Theory . 15 
Distribution and Description of White Snakeroot. 17 
Comparison of White Snakeroot with Related Species. 19 
Names of the Disease. 19 
Clinical History . 20 
Symptoms: 
a. In Cattle ... 20 
b. In Sheep . 22 
c. In Hogs . 23 
d. In Guinea Pigs . 24 
e. In Man . 24 
Mortality in Milksickness . 25 
Experimental Procedure . 26 
Results of Experiments . 28 
Feeding Experiments with White Snakeroot...... 28 
a. With Sheep . 28 
b. With Hogs . 34 
c. With Guinea Pigs . 35 
Transmission of the Disease ... 38 
a. By Milk and Milk Products. 38 
1. To Lambs . 38 
2. To Mice . 40 
b. Through the Agency of Meat. 40 
1. To Dogs .— 40 
Summary of Feeding Experiments ..... 41 
Post-Mortem Examinations . 41 
Clinical Data on Cases . 43 
Temperature, Pulse, and Respiration.43, 45, 49, 52, 55, 58, 60 
Clinical Notes .44, 46, 50, 52, 56, 59, 60 
Blood Study ...44, 47, 50, 53, 56, 61 
Urine Study .47, 51, 53, 56, 63 
Protocol ...44, 48, 51, 54, 57, 59, 61, 63 
Microscopical Examination .45, 48, 52, 54, 58, 60, 62, 63 
Cultural Examination . 63 
Summary of Examinations of Sheep and Lambs... 64 
Nature of the Poisonous Principle. 65 
Means of Prevention and Cure. 67 
General Summary . r . 68 
Literature Cited . 70 
Illustrations . 75 
