The Bulletin 
27 
during the course of these experiments except in animals under experi¬ 
mentation. The flock number of each individual was retained and is 
used subsequently in reporting the experiments with the several animals. 
At first the grain and weed were fed separately; hut since the animals 
either avoided eating any of the weed or ate only sparingly of it, the 
weed was passed through an ensilage cutter and then mixed with grain 
before being fed. A daily account was kept of all of the feed which 
was refused by each animal, and these data were employed in approxi¬ 
mating the total amount consumed during the course of the experiment. 
Since the weed and grain were mixed, and since some loss of weight 
was due to desiccation, the quantity of snakeroot eaten by each animal 
could only be approximated. 
In the experiments with suckling lambs, the ewes and their lambs 
were kept separated except while the lambs took their milk. The ewes 
at these times were put into the pens with the lambs, so that the lambs 
never had access to white snakeroot, as would have been the case had 
the lambs been permitted in the ewes’ pens. 
Before feeding the weed to pigs, which were confined in pens in the 
sheep barn, it was passed through an ensilage cutter and mixed with 
cracked corn and shorts. 
The dogs, which were fed upon the carcasses of sheep dead of trem¬ 
bles, were confined in pens and given, in addition, dog biscuits and refuse 
from the kitchen. 
The guinea pigs which were used in these experiments had never been 
used in experimental work and were consequently entirely normal. 
During the experimentation they were kept in cages especially con¬ 
structed for housing small animals, and were given a diet consisting of 
a mixture of cracked corn, wheat, oats, and rye, which was supple¬ 
mented by green grass and clover. All animals used in any one of the 
experiments to he subsequently reported were kept together in the same 
cage. Each group of animals could thus conveniently be fed twice or 
three times daily with white snakeroot or some of the products pre¬ 
pared from this plant. 
The material extracted by boiling the plant in water, in 2 to 3 per 
cent hydrochloric acid, or alcohol, for twenty-four to forty-eight hours, 
was evaporated to dryness on a water bath, ground into powder, and 
placed in Ho. 2 Lilly Hew Process Gelatine Capsules. The desiccation 
of these products necessitated heating for a long time because of the 
resinous nature of the extracted material. 
The animals were held while feeding them these capsules, and were 
given from six to twelve capsules daily. By the exercise of considerable 
patience, the guinea pigs could be made to masticate and swallow the 
