The Bulletin 
35 
contracted trembles on September 24 and died six days later. This 
animal is shown in figures I, J, K, and L in the accompanying illus- 
• trations. The other animal remained unaffected. 
c. With Guinea Pigs 
Experiment IS .—On June 26, three guinea pigs were placed on an 
experiment which was designed to show whether guinea pigs are sub¬ 
ject to poisoning by the ingestion of green leaves of white snakeroot. 
No. 1 aborted on July 1, refused all feed on that day and on the fol¬ 
lowing day, and was found dead on the morning of July 3. The au¬ 
topsy showed that death very probably resulted from abortion. No. 2 
also aborted on July 1, but her appetite remained quite normal until 
her death which occurred on July 4. She was very inactive, however, 
during this period, but exhibited no other indication of being affected. 
Abortion resulted on June 29 in the case of No. 3. She ate sparingly 
during suceeding days and remained humped up with eyes partially 
closed. Upon being disturbed, she appeared quite active. On July 6 
a period of coma began and death resulted on July 9. Two more ani¬ 
mals, No. 4 and No. 5, were placed in this cage on July 3. On July 9 
No. 4 was very sick and breathed with difficulty. She became comatose 
and was found dead on the morning of July 11. No. 5 appeared nor¬ 
mal until July 10 and was very inactive thereafter until her death on 
July 23. 
Experiment 1J.—Beginning June 26, two male guinea pigs were fed 
on green stems of white snakeroot to determine if stems are as poisonous 
as leaves. No. 1 was noted to be droopy on the morning of July 3 and 
was dead forty-eight hours later. No. 2 was first noted to be affected 
on July 7. He then appeared listless, refused entirely the green stems 
and ate only sparingly of the grain. By July 9 respirations were la¬ 
bored, and he sat crouched in the corner of his cage. His eyes were 
half-closed, his ears drooped, and his head drooped. By July 11 his 
body was limp and he had so lost control of his legs that when lain on 
his side, he could not regain his feet. At this stage, trembling was ap¬ 
parent. The symptoms exhibited in No. 2, which animal is shown in 
Tig. H, are typical of trembles in guinea pigs as developed throughout 
these experiments. This animal was asphyxiated on July 11 and an au¬ 
topsy immediately made. 
Experiment 15 .—At the same time that the above experiments were 
begun to determine whether the leaves and stems are toxic to guinea 
pigs, the feeding of two animals on an aqueous extract was also begun. 
On June 28, some diarrheal symptoms were present, which persisted 
