62 
The Bulletin 
Microscopical Examination. The Liver. —Fatty degeneration, active and 
passive congestion and cloudy swelling are present. 
The Kidneys. —Active and passive congestion are present. The nuclei of 
the parenchymatous cells, in some areas, are picnotic; in others, they stain 
faintly. The protoplasm is granular and the cells swollen. The lumina of 
certain tubules are partially occluded and in some places the lumina of the 
convoluted tubules have disappeared. The nuclei, especially of these convo¬ 
luted tubules, have entirely disappeared and the cells are in a state of ne¬ 
crosis. Many of the glomerules appear shrunken and a wide space can be 
noted between the capillary plexus and the capsule of Bowman. Thus acute 
parenchymatous nephritis with glomerulitis and active and passive conges¬ 
tion are present. 
The Heart. —The blood vessels are congested. 
The Brain. —The brain is congested. This congestion involves both arte¬ 
ries and veins. The spinal cord also shows congestion. 
The Lungs. —Normal. 
The Pancreas. —Normal. 
I 
The Adrenal Gland. —Normal. 
The following microscopic studies were made of the livers and kidneys 
of six guinea pigs : 
Microscopical Examination. Case 1.—Acid extract, No. 1. 
Liver. —Congestion, fatty degeneration, and cloudy swelling are marked. 
Congestion, both active and passive, is more intense than in sheep. 
Kidneys. —The changes in the kidneys include active and passive conges¬ 
tion, fatty degeneration, and cloudy swelling. 
Case 2.—Green stems, No. 2. 
Liver. —Cloudy swelling, fatty degeneration, and active and passive con¬ 
gestion are all present. An occasional area is invaded by polymorphonuclear 
leucocytes. 
Kidneys. —The metamorphoses include active and passive congestion, cloudy 
swelling, and glomerulitis. 
Case 3.— Green leaves. 
Kidneys. —Glomerulitis, active and passive congestion, and cloudy swelling 
are very pronounced. 
Liver. —Active and passive congestion and cloudy swelling are present. 
There are fatty degenerative changes in some areas. 
Case 4.—Expressed juice, No. 1. 
Liver. —Active and passive congestion and cloudy swelling are apparent. 
There are, furthermore, areas showing the beginnings of fatty degeneration. 
Kidney. —The pathological changes include active and passive congestion, 
cloudy swelling, and glomerulitis. 
Cultural studies were made of the blood from the liver, kidneys, and heart. 
Three tubes of agar were inoculated and all except one were negative. In this 
tube, a polar staining, short bacterium was isolated in pure culture. Intra- 
peritoneal inoculation on guinea pigs resulted in no evidence of disease. The 
germ in question was, therefore, considered as a contamination. 
