70 
The Bulletin 
No evidence lias been secured that the flesh of sheep dead of trembles is 
capable of transmitting the disease to dogs, although 11 carcasses were eaten 
by 7 dogs. 
Animals appear to differ greatly in their susceptibility to poisoning, since 
some became affected within a week after feeding on white snakeroot was 
begun, others only after several weeks, and a few remained unaffected. 
10. No detailed studies of the pathological changes accompanying this dis¬ 
ease, other than those of Jordan and Harris, have been made prior to the 
present study. The reports on previous studies seem all to be couched in 
vague, general terms. The present findings agree essentially with those of 
Jordan and Harris. 
11. No febrile condition is present in affected sheep. The most prominent 
changes noted in the 22 autopsies on sheep which were performed consist of 
albuminoid and fatty metamorphoses of the parenchymatous organs. The 
lesions commonly include petecliiation of the epicardium; the presence of a me¬ 
tallic color of the kidneys, which exhibit active and passive congestion and 
cloudy swelling; a “nutmeg” appearance of the liver which has undergone fatty 
changes, and is congested so that blood drips freely from the sectioned sur¬ 
face ; the occurrence of muco-enteritis of the small intestine; and the presence 
of a congestive condition of the brain and meninges. 
12. All attempts to isolate a specific organism from the internal organs of 
six sheep, one hog, and one guinea pig were unsuccessful. This is supported 
indirectly by failure of diseased animals to communicate trembles to healthy 
ones when they are confined together and fed from the same trough. 
13. The active principle is probably glucosidal in nature. 
14. The sodium compounds, salt and soda, appear not to possess antidotal 
effects. In view of the grave cellular changes within the internal organs, 
there is little hope of the efficacy of medication with domestic animals and 
preventive rather than curative measures are to be employed. 
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