Aldrin, Dieldrin, Isodrin, Endrin 
Aldrin was readily converted to dieldrin in the body of beef and dairy 
cattle, pigs, sheep, rats, and poultry (Bann et al., 1956). This change 
was independent of the mode of entry, since it occurred following oral in- 
gestion or subcutaneous injection. 
When aldrin “146 was fed to male rats (Kunze and Lang, 1953; Ludwig et 
al., 1964; Christensen, 1965) or orally injected into male and female rats 
(Heath and Vandekar, 1964), the active material excreted in feces and urine 
consisted of aldrin, dieldrin, and considerable amounts (up to 75% in feces 
and up to 95% in urine) of a mixture of unidentified hydrophilic metabolites. 
At a feeding level of 4.3 mcg per day, a saturation level was reached after 
about eight weeks. Daily excretion of active material approximated the en- 
14 and 13% 
tire activity administered daily. If injected, 16.2% of aldrin-C 
of dieldrin-c!4 was excreted within four hours, via the bile into the intes- 
tinal canal, mainly as hydrophylic compounds (Morsdorf et al., 1963; Korte 
et al., 1963). Recent studies with rat livers showed that this epoxidation 
was performed by the microsomes (Wong and Terriere, 1965). 
Paper chromatography of extracts of feces and urine showed a high per- 
ut initially. The percentage of unchanged aldrin then 
centage of aldrin-C 
decreased while that of hydrophylic metabolites increased continuously for 
about 12 days; and the distribution of excreted compounds remained unchanged 
as long as aldrin was administered daily. After aldrin administration was 
discontinued, the relative percentage of aldrin in feces decreased and diel- 
drin increased (Kunze and Lang, 1953; Ludwig et al., 1964). Paper and thin- 
layer chromatography showed that two different compounds were in the feces; 
18 
