that two different compounds were in the urine; and that one of the compounds 
in feces behaved like one of those in the urine. Hydrolysis of the main 
compound from urine with alcoholic KOH gave a new acidic compound (Ludwig 
et al., 1964). When rabbits were given aldrin intravenously, hydrolysis of 
the metabolites gave the aldrin diol (Korte et al., 1963). 
Dieldrin was administered internally to rats as a single dose of 20 
mg/kg body weight. During the first 8 days, unchanged dieldrin was ex- 
creted in urine. Within the following 4 days, a product of dieldrin was 
excreted. Of the dieldrin administered 15.7% was excreted within 14 days 
in the feces (Rusiecki and Ochynski, 1964). Other feeding studies with rats 
have also shown that dieldrin is metabolized to two compounds more polar 
than dieldrin and unstable to alcoholic KOH (Datta et al., 1965). 
When labeled dieldrin was administered to a rabbit via stomach tube, 
six metabolites were isolated and purified via thin-layer chromatography. 
The main metabolite was identified as one of the two enantiomorphic isomers 
of 6,7-trans dihydroxy-dihydro-aldrin, with a specific rotation of a= -13.7. 
Identification was confirmed by gas dietnaeeiedastie. After intravenous ad- 
ministration of this compound in rats, a more hydrophylic compound was 
found which corresponded to one of the other five compounds found after diel- 
drin administration. It was postulated that a carbonyl group was present 
(Korte and Arent, 1965; Ludwig and Korte, 1965). 
Urine of men with occupational exposure to dieldrin gave evidence that 
dieldrin was eliminated in humans as at least two neutral, polar, chlori- 
nated metabolites, thus'far unidentified (Cueto and Hayes, 1962; Fletcher, 
1959). 
19 
