Application of aldrin to the American cockroach resulted in partial con- 
version to dieldrin (Giannotti et al., 1956). Similarly, tests with locusts 
(Cohen and Smith, 1961), houseflies and mosquito (Aedes Aegypti) larvae 
(Korte et al., 1962; Korte and Stiasni, 1964; Bowman, 1964; Perry et al., 
1964; Gerolt, 1965) showed that labeled aldrin was converted to dieldrin and 
hydrophylic compounds. The sulfur and bromine analogs of dieldrin (s?° and 
pre2 labeled, respectively) also were shown to be partly metabolized to 
water-soluble and insoluble compounds (Winteringham and Harrison, 1959). 
The conversion of aldrin to dieldrin has been found to occur in soil 
(Bollen et al., 1958; Gannon and Bigger, 1958a; Kiigemagi et al., 1958; 
Lichtenstein and Schulz, 1959, 1960; Korte et al., 1962; Wilkinson et al., 
1964) and on plants (Gannon and Decker, 1958a) in general. In 1956, it was 
found that carrots grown in aldrin-treated beds contained dieldrin (Glasser, 
1956). Similarly, peanuts grown in an aldrin-treated bed contained dieldrin 
residues in the hulls, meat, and vine forage (Beck et al., 1962). 
Using molds (Aspergillus niger, Aspergillus flavus, Penicillium nota- 
tum, and Penicillium chrysogenum), labeled insecticides were applied to 
growing cultures. Except for dieldrin, where no conversion could be de- 
tected, considerable amounts of metabolites were found that were more 
hydrophylic than the toxicant applied (Korte et al., 1963). 
When isodrin 14 was applied topically to houseflies, the corresponding 
epoxide endrin and small amounts of a water-insoluble product which be- 
haved as the ketone, a known rearrangement product of endrin, were recovered 
(Brooks and Harrison, 1963). Endrin was not formed in tissues of heat- 
killed insects. Similarly, isodrin was converted to endrin by the American 
cockroach (Periplaneta american L.) (Giannotti, 1958). 
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