acid, for methylene oxide linkage, and for glucuronic acid before and 
after hydrolysis. Tentatively, it was concluded that barthrin in rats 
was metabolized and excreted in the urine as chrysanthemumic acid, 
6-chloropiperonylic acid, and partly as the 6-chloropiperonyl gluc- 
uronide or glycine conjugate. Similar results were obtained with 
Dimethrin (2,4-Dimethylbenzyl chrysanthemumate) (Ambrose, 1964; 
Masri’ et al., 1964). 
The synergist piperonyl cyclonene inhibited the detoxification 
of pyrethrin more than that of allethrin. c-14 jJabeled allethrin 
was metabolized in large part to a polar compound with the same R¢ 
as allethrolone (Hopkins and Robbins, 1957). 
CH 
HAG l 3 
C=CH-CH 0 fH, -CHECH-CH=CHy 
H3C’ cyt ~ cH-C-0-ch c7 
30” 
“SC | 
CHy HyC-——C. 
0 
Pyrethrin I 
rs Fis 
‘c= =CH-CH Ke 
Oe c/ *. (Soot C-0-CM St-CH, -CH=CH-CH=CH, 
CHO” | | 
oe Ho Cy 
Pyrethrin II 
23 
