Amitrole (AT, ATA, 3-AT, Aminotriazole) (3-Amino-1,2,4-triazole) 
Labeled amitrole (3-amino-1,2,4-triazole-5-cl4y was fed to rats. 
Analysis for radioactivity showed only traces of ci4 in expired air. 
Seventy to ninety-five percent of the activity appeared in the urine within 
24 hours as two unidentified metabolites and unchanged amitrole (Fang et al., 
1964b). Feces contained small variable amounts of activity. After the 
first ‘day, most internal organs exhibited some activity. No free amitrole 
was found in the liver. 
Studies have been conducted with amitrole applied to plants (Castel- 
franco and Brown, 1963a; Castelfranco et al., 1963; Onley and Storherr, 
1963) but metabolites were not identified. Other studies indicated that 
amitrole was activated to form a free radical, which was then capable of 
reacting with amino acids (Carter and Naylor, 1960, 196la, b; Herrett and 
Bagley, 1964; Herrett and Linck, 1961; Miller and Hall, 1961). Complexes 
of amitrole and alanine, glycine, or serine have been reported (Carter and 
Naylor, 1959; Margoliash et al., 1960; Margoliash and Schejter, 1962; 
Massini, 1959, 1963; McWhorter, 1963; Naylor, 1964; Rogers, 1957a, b; 
Carter, 1965). Infrared absorption spectral analyses and biochemical studies 
have also indicated that an amine glucoside is formed (Ercegovich and 
Frear, 1964; Frederick, 1961; Frederick and Gentile, 1960a, b, 1961; 
Gentile and Frederick, 1959). Studies showed that the amitrole-glucoside 
could be phosphorylated by yeast (Frederick and Gentile, 1962). 
Recent studies showed that the reproductive and vegetative structures 
of the bean plant, Phaseolus vulgaris, differed in their metabolism of 
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