Y-BHC (Lindane) (gamma 1,2,3,4,5,6-Hexachlorocyclohexane) 
Radiochemical methods used to study the fate of y-BHC in flies showed 
that no respired gases contained cl4, Although most of the radioactivity 
could be extracted by carbon tetrachloride, an unextracted residual activity 
remained in both resistant and normal flies. In addition to pentachloro- 
cyclohexene, some water-soluble metabolites were found (Bradbury and 
Nield, 1953; Bradbury and Standen, 1955, 1958; Bradbury, 1957; Bridges, 
1959; Openoorth, 1954; Sternberg and Kearns, 1956; Ishida and Dahm, 1965b). 
Other studies indicated, however, that the first step in the metabolism 
of y-BHC was the removal of one chlorine atom and the formation of a 
C-S bond, followed by loss of additional chlorine atoms and the formation 
of all six isomers of dichlorothiophenol (Bradbury and Standen, 1959; 
Sims and Grover, 1965). 
When y-BHC was fed to dairy cows (Ware and Gilmore, 1959), no 
pentachlorocyclohexene was found in the milk. Studies with dogs, rabbits, 
and rats indicated a rapid breakdown of BHC into 1,2,4-trichlorobenzene 
and other compounds of unknown structure (Coper et al., 1951; van Asperen 
and Oppenoorth, 1954; San Antonio, 1959; Bronisz et al., 1962; Koransky 
et al., 1964). When labeled q- and y-BHC was administered to rats intra- 
peritoneally, a high concentration of radiating material was present in 
the central nervous system. Both isomers were dechlorinated in vivo and 
converted to water soluble compounds which were excreted by the kidneys 
(Koransky et al., 1963). In rats, urinary excretion reached a peak on 
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