the 5th to 8th day after administration and BHC was not detected after 
17-18 days (Rusiecki et al., 1963). A single oral administration of 
50 or 100 mg of y-BHC/kg body weight of rats increased levels of total 
glucuronic acid excreted in urine during 14-15 days by a daily average 
of 1.5 mg, and organic sulfur compounds by 35-38% during 13-14 days. Thin 
layer and silicic acid column chromatography showed undecomposed y-BHC 
and 2 metabolites in urine and liver for 14 days after administration of 
the BHC (Rusiecki and Bronisz, 1964). 
ae and d -1,3,4,5,6-pentachlorocyclohexene-1 were metabolized by 
rat and liver microsomes in the presence of NADPH, and 0» (Ishida and 
Dahm, 1965a). In other studies, y-BHC and y-2,3,4,5,6-pentachlorocyclohex- 
l-ene were converted by rats into 2,3,5- and #4 evichlovoptionsl and 
excreted in urine as free phenols, sulfates, and glucuronic acid conjugates. 
2,4-Dichloromercapturic acid was also isolated (Grover and Sims, 1965). 
The products found in these studies resemble those in the metabolism of 
1,2,4-trichlorobenzene in rabbits (Jondorf et al., 1955) and it would 
appear that the metabolism of y-BHC proceeds via y-2,3,4,5,6-penta- 
chlorocyclohex-l-ene to 1,2,4-trichlorobenzene. 
Experiments with plants were inconclusive but the data indicated 
pentachlorocyclohexene as a metabolite (Bogdarina, 1957; San Antonio, 
1959). In soil, lindane broke down rapidly to a non-toxic compound of 
undetermined structure (Bradbury and Whitaker, 1956; Lichtenstein and 
Schulz, 1959). 
35 
