and the unsubstituted amide were present in the urine (Menzer and Casida, 
1965). Labeled compounds appeared in the goat milk after treatment with 
either P22 or cl4-1abeled bidrin or SD 9129. No N,N-dimethylacetoacet - 
amide, N-methylacetoacetamide, or 3-hydroxy-N,N-dimethylbutyramide was 
present in the milk and the nature of the C!4 materials remained unknown. 
The major organoextractable P32 material in the milk following both bidrin 
and SD 9129 treatment was SD 9129. Traces of the N-methyl-N-hydroxy- 
methylamide and the unsubstituted amide were also present (Menzer and 
Casida, 1965). 
Urinalyses on dogs, mice, and rabbits, as well as on rats and goats, 
indicated that species variation existed in the rate at which bidrin-P22 
was metabolized and the extent of metabolite excretion in the urine (Menzer 
and Casida, 1965). 
Adult boll weevils and fifth-instar bollworm larvae were treated with 
labeled bidrin. Metabolites recovered were similar to those recovered 
from rats (Bull and Lindquist, 1964). Houseflies and American cockroaches 
rapidly metabolized bidrin and SD 9129 to form the N-hydroxymethyl and 
N-demethylated derivatives detected in urine and milk. Comparatively 
large amounts of the N-hydroxymethylamide compounds were detected in flies 
treated with bidrin or SD 9129 alone but they were absent from extracts of 
flies treated with the toxicant plus sesamex; and only minute amounts of 
SD 9129 were detected in flies treated with bidrin plus sesamex (Menzer 
and Casida, 1965; Hall and Sun, 1965). 
When cotton plants and leaves were treated with bidrin, initial 
detoxification included hydrolysis of the vinyl-phosphate bond to form 
39 
