Biphenyl and 4-Chlorobiphenyl 
After rabbits ingested biphenyl or 4-chlorobiphenyl, 64% and 65%, 
respectively, was accounted for in the urine primarily as the correspond- 
ing glucosiduronic acid and smaller amounts of phenols and ether sulfates. 
From the urine, 4-hydroxybiphenyl and 4-biphenyl glucosiduronic acid 
were isolated and identified after ingestion of biphenyl. After ingestion 
of 4-Chlorobiphenyl, 4-(p-Chlorophenyl) phenol and the corresponding 
glucosiduronic acid were also isolated from the urine. The ethereal sulfates 
were not identified (Block and Cornish, 1959). In the urine of the rat, 
4-hydroxy-, 4,4'-dihydroxy- and 3,4-dihydroxybiphenyl and their conjugates 
and biphenylmercapturic aeaarwehe found (West et al., 1956). 
Liver microsomal preparations from New Zealand white rabbits converted 
biphenyl into 2- and 4-hydroxybiphenyl (Mitoma et al., 1956). Other studies 
with rabbits, indicated that the 4-isomer and practically no 2-isomer 
were formed (Creaven et al., 1965). The extent of 4-hydroxylation varies 
with species, being poor in cat and trout and high in mouse and coypu. 
Ability to form 2-hydroxybiphenyl is almost absent in livers of adult 
rabbits and rats, guinea pigs, hens, trout, and fox. Livers of mice, 
hamsters, cats, coypus, frogs, and young rabbits and rats form measurable 
amounts of the 2-isomer (Creaven et al., 1965). 
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