Coral (Bayer 21/199, Muscatox) (0,0-Diethyl-0-[3-chloro-4-methylum- 
belliferone] phosphorothioate) 
Dermal administration of coral-p?2 to rats gave two peaks of radio- 
activity in the tissues. The first peak appeared between 4 and 6 hours 
following administration; the second, 4 to 7 days later. ‘Two thirds of the 
excreted material appeared in the urine within 28 days, compared with four 
fifths within 18 days of subcutaneous and 14 days of oral administration 
(Lindquist et al., 1958; Krueger et al., 1959a; O'Brien and Wolfe, 1959). 
Four metabolites were detected in the urine. During the first 96 
hours after oral treatment, diethyl phosphorothioic acid constituted 50 - 
80% of excreted radioactivity; phosphoric acid, 10 - 20%; diethyl 
phosphoric acid, 10 - 20%; de-ethylated coral and/or its oxygen analog, 
5 - 30%. Following subcutaneous administration, only three metabolites 
were found. There was diethyl phosphorothioic acid but no phosphoric 
acid. After dermal treatment, none of the de-ethylated derivatives were 
found. Phosphoric, diethyl phosphoric, and diethyl phosphorothioic acids 
appeared in about equal proportions (Lindquist et al., 1958; O'Brien and 
Wolfe, 1959; Vickery and Arthur, 1960). 
After subcutaneous administration, 17% of the radioactivity in the 
feces appeared to be coral or its oxygen analog. Oral and dermal admin- 
istration resulted in an increase to 50 - 60%. When the oxygen analog 
was orally administered, 10% appeared as diethyl phosphoric acid and 40% 
as the de-ethylated analog in the urine with 24 hours (O'Brien and Wolfe, 
1959). 
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