topically treated with pot-c!4, two metabolites were detected, kelthane and 
a compound that behaved like 4,4'-dichlorobenzohydrol. The latter also 
appeared after tipical treatment with kelthane (Agosin et al., 1964). 
Cockroaches metabolized DDT to DDE (Robbins and Dahm, 1955; Cochran, 
1956; Hoskins et al., 1957) and a water soluble compound which, upon acid 
hydrolysis, could be completely extracted by ether in 4 hours (Vinson and 
Kearns, 1952; Butts et al., 1953). This led to speculation that the water 
soluble material was a conjugate composed of a DDT metabolite and possibly 
a carbohydrate. Similar results were obtained with labeled DDT and house- 
flies (Terriere and Schonbrod, 1955). Some studies indicated that metabolism 
of DDT might not always proceed through DDE. Using a DDT-resistant strain 
of the human body louse (Perry and Buckner, 1958a), it was found that DDT 
was metabolized to a water soluble compound that behaved like p-chloroben- 
zoic acid. In subsequent studies, DDT was metabolized to dichlorobenzo- 
phenone (DBP) via DDA or to DDE (Perry and Buckner, 1963). Investigations 
have shown that DDT may be metabolized by insects to as many as 7 metabolites, 
in addition to DDE, most of which are more polar than DDT. All remained 
unidentified (Lindquist and Dahm, 1956; Hoskins and Witt, 1958). 
From mammals fed or exposed to ‘DDI (Stohlman and Smith, 1945; White 
and Sweeney, 1945; Spicer et al., 1947; Carter et al., 1949; Mattson et al., 
1953; Cueto et al., 1956; Hayes et al., 1956; Rothe et al., 1957), DDE, 
DDA, and 4,4'-dichlorobenzophenone have been isolated and identified. 
Using por-c!4, DDE has been found in both bile and feces (Burns et al., 
1957; Jensen et al., 1957). DDA, both complexed and free, has also been 
found. Stability to alkaline hydrolysis and negative qualitative tests 
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