Diazinon (0,0-diethyl 0O-[2-isopropyl-4-methyl1-6 pyrimidiny1] phosphorothioate) 
Studies with mice and insects have been conducted. The only metab- 
olite identified was the P = O analog (Robbins et al., 1957; Gysin and 
Margot, 1958; Krueger et al., 1960; Forgash et al., 1962). In cows, the 
diethylphosphorothioic and phosphoric acids were found (Robbins et al., 1965). 
NZ 
opel ad -P-OCH. es “nm 
oc aHs 3 OCH, 
Dibrom (1,2 dibromo -2,2-dichloroethyl dimethyl phosphate) 
Adult male rats were treated with dibrom-P32 in corn oil by stomach 
tube. Within a day, high activity appeared in the bone. 
-p32 to a cow, urine yielded p32_ 
After oral administration of dibrom 
metabolites chromatographing in the position of inorganic phosphate, mono- 
and dimethyl phosphate, and O-methyl 2,2-dichlorovinyl phosphate, DDVP, 
dichloroacetaldehyde, dichlorobromoacetaldehyde. Studies indicated that 
dibrom reacts with sulfhydryls and that certain complex amino acid conjugates 
of the degraded products are also formed (Casida et al., 1962; Kohn et al., 
1960). 
85 
